Data from: Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations

Kurzanzeige
dc.contributor.authorKratochwil, Claudius F.
dc.contributor.authorLiang, Yipeng
dc.contributor.authorGerwin, Jan
dc.contributor.authorWoltering, Joost M.
dc.contributor.authorUrban, Sabine
dc.contributor.authorHenning, Frederico
dc.contributor.authorMachado-Schiaffino, Gonzalo
dc.contributor.authorHulsey, C. Darrin
dc.contributor.authorMeyer, Axel
dc.date.accessioned2026-01-19T16:46:41Z
dc.date.available2026-01-19T16:46:41Z
dc.date.created2018-10-04T20:49:45Z
dc.date.issued2018
dc.description.abstractThe color patterns of African cichlid fishes provide notable examples of phenotypic convergence. Across the more than 1200 East African rift lake species, melanic horizontal stripes have evolved numerous times. We discovered that regulatory changes of the gene agouti-related peptide 2 (agrp2) act as molecular switches controlling this evolutionarily labile phenotype. Reduced agrp2 expression is convergently associated with the presence of stripe patterns across species flocks. However, cis-regulatory mutations are not predictive of stripes across radiations, suggesting independent regulatory mechanisms. Genetic mapping confirms the link between the agrp2 locus and stripe patterns. The crucial role of agrp2 is further supported by a CRISPR-Cas9 knockout that reconstitutes stripes in a nonstriped cichlid. Thus, we unveil how a single gene affects the convergent evolution of a complex color pattern.
dc.description.versionpublisheddeu
dc.identifier.doi10.5061/dryad.h1107nd
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/75758
dc.language.isoeng
dc.rightsCreative Commons Zero v1.0 Universal
dc.rights.urihttps://creativecommons.org/publicdomain/zero/1.0/legalcode
dc.subjectHaplochromis chilotes
dc.subjectLamprologus multifasciatus
dc.subjectAulonocara jacobfreibergi
dc.subjectHaplochromis paropius
dc.subjectagrp2
dc.subjectHaplochromis serranus
dc.subjectJulidochromis regani
dc.subjectPlacidochromis johnstoni
dc.subjectPseudotropheus cyaneorhabdos
dc.subjectHaplochromis melanopterus
dc.subjectPundamilia nyererei
dc.subjectDimidiochromis compressiceps
dc.subjectHaplochromis latifasciata
dc.subjectCheilochromis euchilus
dc.subjectNeolamprologus cylindricus
dc.subjectHaplochromis vonlinnei
dc.subjectHaplochromis sauvagei
dc.subjectNeolamprologus caudopunctatus
dc.subjectHaplochromis thereuterion
dc.subjectColor patterns
dc.subjectJulidochromis marlieri
dc.subjectNeolamprologus brichardi
dc.subjectTeleosts
dc.subjectHarpagochromis sp. orange rock hunter
dc.subjectPseudotropheus demasoni
dc.subjectMaylandi zebra
dc.subjectPundamilia pundamilia
dc.subjectOreochromis niloticus
dc.subjectJulidochromis ornatus
dc.subjectMelanochromis auratus
dc.subjectTelmatochromis vittatus
dc.subjectLabidochromis caeruleus
dc.subject.ddc570
dc.titleData from: Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiationseng
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kops.citation.iso690KRATOCHWIL,  Claudius F.,  Yipeng LIANG,  Jan GERWIN,  Joost M. WOLTERING,  Sabine URBAN,  Frederico HENNING,  Gonzalo MACHADO-SCHIAFFINO,  Christopher Darrin HULSEY,  Axel MEYER, 2018. Data from: Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiationsdeu
kops.citation.iso690KRATOCHWIL,  Claudius F.,  Yipeng LIANG,  Jan GERWIN,  Joost M. WOLTERING,  Sabine URBAN,  Frederico HENNING,  Gonzalo MACHADO-SCHIAFFINO,  Christopher Darrin HULSEY,  Axel MEYER, 2018. Data from: Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiationseng
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