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Data from: Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations

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2018

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DRYAD

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DOI (Link zu den Daten)
https://doi.org/10.5061/dryad.h1107nd
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Creative Commons Zero v1.0 Universal

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Published

Zusammenfassung

The color patterns of African cichlid fishes provide notable examples of phenotypic convergence. Across the more than 1200 East African rift lake species, melanic horizontal stripes have evolved numerous times. We discovered that regulatory changes of the gene agouti-related peptide 2 (agrp2) act as molecular switches controlling this evolutionarily labile phenotype. Reduced agrp2 expression is convergently associated with the presence of stripe patterns across species flocks. However, cis-regulatory mutations are not predictive of stripes across radiations, suggesting independent regulatory mechanisms. Genetic mapping confirms the link between the agrp2 locus and stripe patterns. The crucial role of agrp2 is further supported by a CRISPR-Cas9 knockout that reconstitutes stripes in a nonstriped cichlid. Thus, we unveil how a single gene affects the convergent evolution of a complex color pattern.

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570 Biowissenschaften, Biologie

Schlagwörter

Haplochromis chilotes, Lamprologus multifasciatus, Aulonocara jacobfreibergi, Haplochromis paropius, agrp2, Haplochromis serranus, Julidochromis regani, Placidochromis johnstoni, Pseudotropheus cyaneorhabdos, Haplochromis melanopterus, Pundamilia nyererei, Dimidiochromis compressiceps, Haplochromis latifasciata, Cheilochromis euchilus, Neolamprologus cylindricus, Haplochromis vonlinnei, Haplochromis sauvagei, Neolamprologus caudopunctatus, Haplochromis thereuterion, Color patterns, Julidochromis marlieri, Neolamprologus brichardi, Teleosts, Harpagochromis sp. orange rock hunter, Pseudotropheus demasoni, Maylandi zebra, Pundamilia pundamilia, Oreochromis niloticus, Julidochromis ornatus, Melanochromis auratus, Telmatochromis vittatus, Labidochromis caeruleus

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Zeitschriftenartikel
Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations
(2018) Kratochwil, Claudius F.; Liang, Yipeng; Gerwin, Jan; Woltering, Joost M.; Urban, Sabine; Henning, Frederico; Machado-Schiaffino, Gonzalo; Hulsey, Christopher Darrin; Meyer, Axel
Erschienen in: Science. 2018, 362(6413), S. 457-460. ISSN 0036-8075. eISSN 1095-9203. Verfügbar unter: doi: 10.1126/science.aao6809
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ISO 690KRATOCHWIL, Claudius F., Yipeng LIANG, Jan GERWIN, Joost M. WOLTERING, Sabine URBAN, Frederico HENNING, Gonzalo MACHADO-SCHIAFFINO, Christopher Darrin HULSEY, Axel MEYER, 2018. Data from: Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations
BibTex
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