CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

Kurzanzeige
dc.contributor.authorZhou, Tiankun
dc.contributor.authorFleming, Jennifer R.
dc.contributor.authorFranke, Barbara
dc.contributor.authorBogomolovas, Julius
dc.contributor.authorBarsukov, Igor
dc.contributor.authorRigden, Daniel J.
dc.contributor.authorLabeit, Siegfried
dc.contributor.authorMayans, Olga
dc.date.accessioned2017-01-10T13:22:33Z
dc.date.available2017-01-10T13:22:33Z
dc.date.issued2016-09eng
dc.description.abstractThe cardiac ankyrin repeat protein (CARP) is up-regulated in the myocardium during cardiovascular disease and in response to mechanical or toxic stress. Stress-induced CARP interacts with the N2A spring region of the titin filament to modulate muscle compliance. We characterize the interaction between CARP and titin-N2A and show that the binding site in titin spans the dual domain UN2A-Ig81. We find that the unique sequence UN2A is not structurally disordered, but that it has a stable, elongated α-helical fold that possibly acts as a constant force spring. Our findings portray CARP/titin-N2A as a structured node and help to rationalize the molecular basis of CARP mechanosensing in the sarcomeric I-band.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1002/1873-3468.12362eng
dc.identifier.pmid27531639eng
dc.identifier.ppn492412227
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/36547
dc.language.isoengeng
dc.rightsterms-of-use
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/
dc.subject.ddc570eng
dc.titleCARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complexeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Zhou2016-09inter-36547,
  year={2016},
  doi={10.1002/1873-3468.12362},
  title={CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex},
  number={18},
  volume={590},
  issn={0014-5793},
  journal={FEBS Letters},
  pages={3098--3110},
  author={Zhou, Tiankun and Fleming, Jennifer R. and Franke, Barbara and Bogomolovas, Julius and Barsukov, Igor and Rigden, Daniel J. and Labeit, Siegfried and Mayans, Olga}
}
kops.citation.iso690ZHOU, Tiankun, Jennifer R. FLEMING, Barbara FRANKE, Julius BOGOMOLOVAS, Igor BARSUKOV, Daniel J. RIGDEN, Siegfried LABEIT, Olga MAYANS, 2016. CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex. In: FEBS Letters. 2016, 590(18), pp. 3098-3110. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1002/1873-3468.12362deu
kops.citation.iso690ZHOU, Tiankun, Jennifer R. FLEMING, Barbara FRANKE, Julius BOGOMOLOVAS, Igor BARSUKOV, Daniel J. RIGDEN, Siegfried LABEIT, Olga MAYANS, 2016. CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex. In: FEBS Letters. 2016, 590(18), pp. 3098-3110. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1002/1873-3468.12362eng
kops.citation.rdf
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36547">
    <dc:contributor>Bogomolovas, Julius</dc:contributor>
    <dc:language>eng</dc:language>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Fleming, Jennifer R.</dc:contributor>
    <dc:contributor>Labeit, Siegfried</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/36547/1/Zhou_0-383148.pdf"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/36547/1/Zhou_0-383148.pdf"/>
    <dc:creator>Zhou, Tiankun</dc:creator>
    <dcterms:abstract xml:lang="eng">The cardiac ankyrin repeat protein (CARP) is up-regulated in the myocardium during cardiovascular disease and in response to mechanical or toxic stress. Stress-induced CARP interacts with the N2A spring region of the titin filament to modulate muscle compliance. We characterize the interaction between CARP and titin-N2A and show that the binding site in titin spans the dual domain UN2A-Ig81. We find that the unique sequence UN2A is not structurally disordered, but that it has a stable, elongated α-helical fold that possibly acts as a constant force spring. Our findings portray CARP/titin-N2A as a structured node and help to rationalize the molecular basis of CARP mechanosensing in the sarcomeric I-band.</dcterms:abstract>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:contributor>Mayans, Olga</dc:contributor>
    <dc:creator>Barsukov, Igor</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Labeit, Siegfried</dc:creator>
    <dc:creator>Mayans, Olga</dc:creator>
    <dc:creator>Fleming, Jennifer R.</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-10T13:22:33Z</dcterms:available>
    <dc:contributor>Zhou, Tiankun</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-10T13:22:33Z</dc:date>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:title>CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex</dcterms:title>
    <dc:contributor>Barsukov, Igor</dc:contributor>
    <dc:creator>Bogomolovas, Julius</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/36547"/>
    <dc:contributor>Franke, Barbara</dc:contributor>
    <dcterms:issued>2016-09</dcterms:issued>
    <dc:contributor>Rigden, Daniel J.</dc:contributor>
    <dc:creator>Rigden, Daniel J.</dc:creator>
    <dc:creator>Franke, Barbara</dc:creator>
  </rdf:Description>
</rdf:RDF>
kops.description.openAccessopenaccessgreen
kops.flag.knbibliographytrue
kops.identifier.nbnurn:nbn:de:bsz:352-0-383148
kops.sourcefieldFEBS Letters. 2016, <b>590</b>(18), pp. 3098-3110. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1002/1873-3468.12362deu
kops.sourcefield.plainFEBS Letters. 2016, 590(18), pp. 3098-3110. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1002/1873-3468.12362deu
kops.sourcefield.plainFEBS Letters. 2016, 590(18), pp. 3098-3110. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1002/1873-3468.12362eng
relation.isAuthorOfPublication6ba08b2f-240f-4c8b-9618-bc9c2aff4ed2
relation.isAuthorOfPublicationb81059fa-83b3-4cb2-8f21-e9358a1a9ffa
relation.isAuthorOfPublication70169e48-0c0d-4ff0-99dc-5cac0ca82ad3
relation.isAuthorOfPublication978df80a-b814-4924-aff7-408f7c27cc66
relation.isAuthorOfPublication.latestForDiscovery6ba08b2f-240f-4c8b-9618-bc9c2aff4ed2
source.bibliographicInfo.fromPage3098eng
source.bibliographicInfo.issue18eng
source.bibliographicInfo.toPage3110eng
source.bibliographicInfo.volume590eng
source.identifier.eissn1873-3468eng
source.identifier.issn0014-5793eng
source.periodicalTitleFEBS Letterseng

Dateien

Originalbündel

Gerade angezeigt 1 - 1 von 1
Vorschaubild nicht verfügbar
Name:
Zhou_0-383148.pdf
Größe:
2.21 MB
Format:
Adobe Portable Document Format
Beschreibung:
Zhou_0-383148.pdf
Zhou_0-383148.pdfGröße: 2.21 MBDownloads: 748

Sammlungen

Biologie: Publikationen