CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2016
Autor:innen
Bogomolovas, Julius
Barsukov, Igor
Rigden, Daniel J.
Labeit, Siegfried
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
FEBS Letters. 2016, 590(18), pp. 3098-3110. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1002/1873-3468.12362
Zusammenfassung

The cardiac ankyrin repeat protein (CARP) is up-regulated in the myocardium during cardiovascular disease and in response to mechanical or toxic stress. Stress-induced CARP interacts with the N2A spring region of the titin filament to modulate muscle compliance. We characterize the interaction between CARP and titin-N2A and show that the binding site in titin spans the dual domain UN2A-Ig81. We find that the unique sequence UN2A is not structurally disordered, but that it has a stable, elongated α-helical fold that possibly acts as a constant force spring. Our findings portray CARP/titin-N2A as a structured node and help to rationalize the molecular basis of CARP mechanosensing in the sarcomeric I-band.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690ZHOU, Tiankun, Jennifer R. FLEMING, Barbara FRANKE, Julius BOGOMOLOVAS, Igor BARSUKOV, Daniel J. RIGDEN, Siegfried LABEIT, Olga MAYANS, 2016. CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex. In: FEBS Letters. 2016, 590(18), pp. 3098-3110. ISSN 0014-5793. eISSN 1873-3468. Available under: doi: 10.1002/1873-3468.12362
BibTex
@article{Zhou2016-09inter-36547,
  year={2016},
  doi={10.1002/1873-3468.12362},
  title={CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex},
  number={18},
  volume={590},
  issn={0014-5793},
  journal={FEBS Letters},
  pages={3098--3110},
  author={Zhou, Tiankun and Fleming, Jennifer R. and Franke, Barbara and Bogomolovas, Julius and Barsukov, Igor and Rigden, Daniel J. and Labeit, Siegfried and Mayans, Olga}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36547">
    <dc:contributor>Bogomolovas, Julius</dc:contributor>
    <dc:language>eng</dc:language>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Fleming, Jennifer R.</dc:contributor>
    <dc:contributor>Labeit, Siegfried</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/36547/1/Zhou_0-383148.pdf"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/36547/1/Zhou_0-383148.pdf"/>
    <dc:creator>Zhou, Tiankun</dc:creator>
    <dcterms:abstract xml:lang="eng">The cardiac ankyrin repeat protein (CARP) is up-regulated in the myocardium during cardiovascular disease and in response to mechanical or toxic stress. Stress-induced CARP interacts with the N2A spring region of the titin filament to modulate muscle compliance. We characterize the interaction between CARP and titin-N2A and show that the binding site in titin spans the dual domain UN2A-Ig81. We find that the unique sequence UN2A is not structurally disordered, but that it has a stable, elongated α-helical fold that possibly acts as a constant force spring. Our findings portray CARP/titin-N2A as a structured node and help to rationalize the molecular basis of CARP mechanosensing in the sarcomeric I-band.</dcterms:abstract>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:contributor>Mayans, Olga</dc:contributor>
    <dc:creator>Barsukov, Igor</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Labeit, Siegfried</dc:creator>
    <dc:creator>Mayans, Olga</dc:creator>
    <dc:creator>Fleming, Jennifer R.</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-10T13:22:33Z</dcterms:available>
    <dc:contributor>Zhou, Tiankun</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-01-10T13:22:33Z</dc:date>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:title>CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex</dcterms:title>
    <dc:contributor>Barsukov, Igor</dc:contributor>
    <dc:creator>Bogomolovas, Julius</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/36547"/>
    <dc:contributor>Franke, Barbara</dc:contributor>
    <dcterms:issued>2016-09</dcterms:issued>
    <dc:contributor>Rigden, Daniel J.</dc:contributor>
    <dc:creator>Rigden, Daniel J.</dc:creator>
    <dc:creator>Franke, Barbara</dc:creator>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen