The unique functions of tissue-specific proteasomes

Kurzanzeige
dc.contributor.authorKniepert, Andrea
dc.contributor.authorGroettrup, Marcus
dc.date.accessioned2014-07-09T15:14:08Zdeu
dc.date.available2014-07-09T15:14:08Zdeu
dc.date.issued2014-01
dc.description.abstractThe 26S proteasome is the main protease in eukaryotes. Proteolysis occurs within the cylindrical 20S proteasome that is constitutively expressed in most tissues. However, three tissue-specific versions of the 20S proteasome have been discovered to date. The immunoproteasome is optimized to process antigens and it directs the differentiation of T helper (Th) cells. The thymoproteasome is selectively expressed in cortical epithelial cells of the thymus where it plays an essential role in the positive selection of T lymphocytes. Finally, the spermatoproteasome is found in the testes where it is required during spermatogenesis. Here, we outline how tissue-specific proteasomes adapt to functional needs in their respective tissues and how their selective inhibition may be used to interfere with autoimmune diseases and cancer.eng
dc.description.versionpublished
dc.identifier.citationTrends in biochemical sciences ; 39 (2014), 1. - S. 17-24deu
dc.identifier.doi10.1016/j.tibs.2013.10.004deu
dc.identifier.pmid24286712
dc.identifier.ppn495375063
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/28324
dc.language.isoengdeu
dc.legacy.dateIssued2014-07-09deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectImmunoproteasomedeu
dc.subjectthymoproteasomedeu
dc.subjectspermatoproteasomedeu
dc.subjectubiquitindeu
dc.subjectantigen presentationdeu
dc.subject.ddc570deu
dc.titleThe unique functions of tissue-specific proteasomeseng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
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  journal={Trends in Biochemical Sciences},
  pages={17--24},
  author={Kniepert, Andrea and Gröttrup, Marcus}
}
kops.citation.iso690KNIEPERT, Andrea, Marcus GRÖTTRUP, 2014. The unique functions of tissue-specific proteasomes. In: Trends in Biochemical Sciences. 2014, 39(1), pp. 17-24. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2013.10.004deu
kops.citation.iso690KNIEPERT, Andrea, Marcus GRÖTTRUP, 2014. The unique functions of tissue-specific proteasomes. In: Trends in Biochemical Sciences. 2014, 39(1), pp. 17-24. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2013.10.004eng
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kops.sourcefield.plainTrends in Biochemical Sciences. 2014, 39(1), pp. 17-24. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2013.10.004eng
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