Publikation:

The unique functions of tissue-specific proteasomes

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Kniepert_283246.pdf
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2014

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http://nbn-resolving.de/urn:nbn:de:bsz:352-283246
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https://doi.org/10.1016/j.tibs.2013.10.004
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Trends in Biochemical Sciences. 2014, 39(1), pp. 17-24. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2013.10.004

Zusammenfassung

The 26S proteasome is the main protease in eukaryotes. Proteolysis occurs within the cylindrical 20S proteasome that is constitutively expressed in most tissues. However, three tissue-specific versions of the 20S proteasome have been discovered to date. The immunoproteasome is optimized to process antigens and it directs the differentiation of T helper (Th) cells. The thymoproteasome is selectively expressed in cortical epithelial cells of the thymus where it plays an essential role in the positive selection of T lymphocytes. Finally, the spermatoproteasome is found in the testes where it is required during spermatogenesis. Here, we outline how tissue-specific proteasomes adapt to functional needs in their respective tissues and how their selective inhibition may be used to interfere with autoimmune diseases and cancer.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Immunoproteasome, thymoproteasome, spermatoproteasome, ubiquitin, antigen presentation

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ISO 690KNIEPERT, Andrea, Marcus GRÖTTRUP, 2014. The unique functions of tissue-specific proteasomes. In: Trends in Biochemical Sciences. 2014, 39(1), pp. 17-24. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2013.10.004
BibTex
@article{Kniepert2014-01uniqu-28324,
  year={2014},
  doi={10.1016/j.tibs.2013.10.004},
  title={The unique functions of tissue-specific proteasomes},
  number={1},
  volume={39},
  issn={0968-0004},
  journal={Trends in Biochemical Sciences},
  pages={17--24},
  author={Kniepert, Andrea and Gröttrup, Marcus}
}
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