Application of “Omics” Technologies to In Vitro Toxicology

Kurzanzeige
dc.contributor.authorStiegler, Nina
dc.contributor.authorDao, Tyna
dc.contributor.authorLeist, Marcel
dc.contributor.authorVoijnits, Kinga
dc.contributor.authorWaldmann, Tanja
dc.contributor.authorZhao, Liang
dc.contributor.authorHogberg, Helena T.
dc.contributor.authorvan Vliet, Erwin
dc.date.accessioned2015-03-04T11:00:47Z
dc.date.available2015-03-04T11:00:47Z
dc.date.issued2014eng
dc.description.abstract“Omics” technologies have facilitated significant advances in the understanding of toxicity mechanisms in complex biological systems. In this chapter we discuss the most important “omics” technologies and how they are currently applied in the field of in vitro toxicology. For each technology, advantages, limitations, and developmental needs are addressed. In addition, we provide some future prospects on the role of “omics” technologies in the emerging new paradigm of mechanistic toxicity studies. It becomes clear that technological developments have enhanced the application of “omics” technologies in toxicology and simplified the interpretation of the generated information; nevertheless, significant challenges remain to incorporate “omics” technologies and “omics” data in the regulatory decision making process.eng
dc.description.versionpublished
dc.identifier.doi10.1007/978-1-4939-0521-8_18eng
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/30151
dc.language.isoengeng
dc.subjectTranscriptomics, Proteomics, Metabolomics, Epigenetics, Systems biologyeng
dc.subject.ddc570eng
dc.titleApplication of “Omics” Technologies to In Vitro Toxicologyeng
dc.typeINCOLLECTIONeng
dspace.entity.typePublication
kops.citation.bibtex
@incollection{Stiegler2014Appli-30151,
  year={2014},
  doi={10.1007/978-1-4939-0521-8_18},
  title={Application of “Omics” Technologies to In Vitro Toxicology},
  number={1557-2153},
  isbn={978-1-4939-0520-1},
  publisher={Springer},
  address={New York},
  series={Methods in Pharmacology and Toxicology},
  booktitle={In Vitro Toxicology Systems},
  pages={399--432},
  editor={Anna Bal-Price ...},
  author={Stiegler, Nina and Dao, Tyna and Leist, Marcel and Voijnits, Kinga and Waldmann, Tanja and Zhao, Liang and Hogberg, Helena T. and van Vliet, Erwin}
}
kops.citation.iso690STIEGLER, Nina, Tyna DAO, Marcel LEIST, Kinga VOIJNITS, Tanja WALDMANN, Liang ZHAO, Helena T. HOGBERG, Erwin VAN VLIET, 2014. Application of “Omics” Technologies to In Vitro Toxicology. In: ANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18deu
kops.citation.iso690STIEGLER, Nina, Tyna DAO, Marcel LEIST, Kinga VOIJNITS, Tanja WALDMANN, Liang ZHAO, Helena T. HOGBERG, Erwin VAN VLIET, 2014. Application of “Omics” Technologies to In Vitro Toxicology. In: ANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18eng
kops.citation.rdf
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/30151">
    <dcterms:title>Application of “Omics” Technologies to In Vitro Toxicology</dcterms:title>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Zhao, Liang</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-03-04T11:00:47Z</dcterms:available>
    <dc:creator>van Vliet, Erwin</dc:creator>
    <dc:contributor>Dao, Tyna</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Voijnits, Kinga</dc:creator>
    <dcterms:issued>2014</dcterms:issued>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Leist, Marcel</dc:creator>
    <dc:creator>Dao, Tyna</dc:creator>
    <dc:creator>Stiegler, Nina</dc:creator>
    <dc:contributor>Stiegler, Nina</dc:contributor>
    <dc:contributor>Hogberg, Helena T.</dc:contributor>
    <dcterms:abstract xml:lang="eng">“Omics” technologies have facilitated significant advances in the understanding of toxicity mechanisms in complex biological systems. In this chapter we discuss the most important “omics” technologies and how they are currently applied in the field of in vitro toxicology. For each technology, advantages, limitations, and developmental needs are addressed. In addition, we provide some future prospects on the role of “omics” technologies in the emerging new paradigm of mechanistic toxicity studies. It becomes clear that technological developments have enhanced the application of “omics” technologies in toxicology and simplified the interpretation of the generated information; nevertheless, significant challenges remain to incorporate “omics” technologies and “omics” data in the regulatory decision making process.</dcterms:abstract>
    <dc:creator>Hogberg, Helena T.</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Waldmann, Tanja</dc:contributor>
    <dc:creator>Waldmann, Tanja</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>van Vliet, Erwin</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-03-04T11:00:47Z</dc:date>
    <dc:contributor>Voijnits, Kinga</dc:contributor>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/30151"/>
    <dc:contributor>Zhao, Liang</dc:contributor>
  </rdf:Description>
</rdf:RDF>
kops.flag.knbibliographytrue
kops.sourcefieldANNA BAL-PRICE ..., , ed.. <i>In Vitro Toxicology Systems</i>. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18deu
kops.sourcefield.plainANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18deu
kops.sourcefield.plainANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18eng
relation.isAuthorOfPublicatione9c0c8cd-cc4a-40b8-bec3-ad73b687602f
relation.isAuthorOfPublicationd166cc79-683e-4b5f-b4a0-8ccdd3d02bbc
relation.isAuthorOfPublication22439442-4599-40bc-93f9-1ca7b69b0787
relation.isAuthorOfPublication.latestForDiscoverye9c0c8cd-cc4a-40b8-bec3-ad73b687602f
source.bibliographicInfo.fromPage399eng
source.bibliographicInfo.seriesNumber1557-2153eng
source.bibliographicInfo.toPage432eng
source.contributor.editorAnna Bal-Price ...eng
source.identifier.isbn978-1-4939-0520-1eng
source.publisherSpringereng
source.publisher.locationNew Yorkeng
source.relation.ispartofseriesMethods in Pharmacology and Toxicologyeng
source.titleIn Vitro Toxicology Systemseng
temp.internal.duplicates<p>Keine Dubletten gefunden. Letzte Überprüfung: 08.12.2014 16:05:16</p>deu

Dateien

Sammlungen

Biologie: Publikationen