Application of “Omics” Technologies to In Vitro Toxicology

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2014
Autor:innen
Dao, Tyna
Voijnits, Kinga
Zhao, Liang
Hogberg, Helena T.
van Vliet, Erwin
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Publikationstyp
Beitrag zu einem Sammelband
Publikationsstatus
Published
Erschienen in
ANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18
Zusammenfassung

“Omics” technologies have facilitated significant advances in the understanding of toxicity mechanisms in complex biological systems. In this chapter we discuss the most important “omics” technologies and how they are currently applied in the field of in vitro toxicology. For each technology, advantages, limitations, and developmental needs are addressed. In addition, we provide some future prospects on the role of “omics” technologies in the emerging new paradigm of mechanistic toxicity studies. It becomes clear that technological developments have enhanced the application of “omics” technologies in toxicology and simplified the interpretation of the generated information; nevertheless, significant challenges remain to incorporate “omics” technologies and “omics” data in the regulatory decision making process.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Transcriptomics, Proteomics, Metabolomics, Epigenetics, Systems biology
Konferenz
Rezension
undefined / . - undefined, undefined
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Datensätze
Zitieren
ISO 690STIEGLER, Nina, Tyna DAO, Marcel LEIST, Kinga VOIJNITS, Tanja WALDMANN, Liang ZHAO, Helena T. HOGBERG, Erwin VAN VLIET, 2014. Application of “Omics” Technologies to In Vitro Toxicology. In: ANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18
BibTex
@incollection{Stiegler2014Appli-30151,
  year={2014},
  doi={10.1007/978-1-4939-0521-8_18},
  title={Application of “Omics” Technologies to In Vitro Toxicology},
  number={1557-2153},
  isbn={978-1-4939-0520-1},
  publisher={Springer},
  address={New York},
  series={Methods in Pharmacology and Toxicology},
  booktitle={In Vitro Toxicology Systems},
  pages={399--432},
  editor={Anna Bal-Price ...},
  author={Stiegler, Nina and Dao, Tyna and Leist, Marcel and Voijnits, Kinga and Waldmann, Tanja and Zhao, Liang and Hogberg, Helena T. and van Vliet, Erwin}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/30151">
    <dcterms:title>Application of “Omics” Technologies to In Vitro Toxicology</dcterms:title>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Zhao, Liang</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-03-04T11:00:47Z</dcterms:available>
    <dc:creator>van Vliet, Erwin</dc:creator>
    <dc:contributor>Dao, Tyna</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Voijnits, Kinga</dc:creator>
    <dcterms:issued>2014</dcterms:issued>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Leist, Marcel</dc:creator>
    <dc:creator>Dao, Tyna</dc:creator>
    <dc:creator>Stiegler, Nina</dc:creator>
    <dc:contributor>Stiegler, Nina</dc:contributor>
    <dc:contributor>Hogberg, Helena T.</dc:contributor>
    <dcterms:abstract xml:lang="eng">“Omics” technologies have facilitated significant advances in the understanding of toxicity mechanisms in complex biological systems. In this chapter we discuss the most important “omics” technologies and how they are currently applied in the field of in vitro toxicology. For each technology, advantages, limitations, and developmental needs are addressed. In addition, we provide some future prospects on the role of “omics” technologies in the emerging new paradigm of mechanistic toxicity studies. It becomes clear that technological developments have enhanced the application of “omics” technologies in toxicology and simplified the interpretation of the generated information; nevertheless, significant challenges remain to incorporate “omics” technologies and “omics” data in the regulatory decision making process.</dcterms:abstract>
    <dc:creator>Hogberg, Helena T.</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Waldmann, Tanja</dc:contributor>
    <dc:creator>Waldmann, Tanja</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>van Vliet, Erwin</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-03-04T11:00:47Z</dc:date>
    <dc:contributor>Voijnits, Kinga</dc:contributor>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/30151"/>
    <dc:contributor>Zhao, Liang</dc:contributor>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen