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Application of “Omics” Technologies to In Vitro Toxicology

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2014

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Dao, Tyna
Voijnits, Kinga
Zhao, Liang
Hogberg, Helena T.
van Vliet, Erwin

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https://doi.org/10.1007/978-1-4939-0521-8_18
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ANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18

Zusammenfassung

“Omics” technologies have facilitated significant advances in the understanding of toxicity mechanisms in complex biological systems. In this chapter we discuss the most important “omics” technologies and how they are currently applied in the field of in vitro toxicology. For each technology, advantages, limitations, and developmental needs are addressed. In addition, we provide some future prospects on the role of “omics” technologies in the emerging new paradigm of mechanistic toxicity studies. It becomes clear that technological developments have enhanced the application of “omics” technologies in toxicology and simplified the interpretation of the generated information; nevertheless, significant challenges remain to incorporate “omics” technologies and “omics” data in the regulatory decision making process.

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570 Biowissenschaften, Biologie

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Transcriptomics, Proteomics, Metabolomics, Epigenetics, Systems biology

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ISO 690STIEGLER, Nina, Tyna DAO, Marcel LEIST, Kinga VOIJNITS, Tanja WALDMANN, Liang ZHAO, Helena T. HOGBERG, Erwin VAN VLIET, 2014. Application of “Omics” Technologies to In Vitro Toxicology. In: ANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18
BibTex
@incollection{Stiegler2014Appli-30151,
  year={2014},
  doi={10.1007/978-1-4939-0521-8_18},
  title={Application of “Omics” Technologies to In Vitro Toxicology},
  number={1557-2153},
  isbn={978-1-4939-0520-1},
  publisher={Springer},
  address={New York},
  series={Methods in Pharmacology and Toxicology},
  booktitle={In Vitro Toxicology Systems},
  pages={399--432},
  editor={Anna Bal-Price ...},
  author={Stiegler, Nina and Dao, Tyna and Leist, Marcel and Voijnits, Kinga and Waldmann, Tanja and Zhao, Liang and Hogberg, Helena T. and van Vliet, Erwin}
}
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