Publikation: Application of “Omics” Technologies to In Vitro Toxicology
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
“Omics” technologies have facilitated significant advances in the understanding of toxicity mechanisms in complex biological systems. In this chapter we discuss the most important “omics” technologies and how they are currently applied in the field of in vitro toxicology. For each technology, advantages, limitations, and developmental needs are addressed. In addition, we provide some future prospects on the role of “omics” technologies in the emerging new paradigm of mechanistic toxicity studies. It becomes clear that technological developments have enhanced the application of “omics” technologies in toxicology and simplified the interpretation of the generated information; nevertheless, significant challenges remain to incorporate “omics” technologies and “omics” data in the regulatory decision making process.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
STIEGLER, Nina, Tyna DAO, Marcel LEIST, Kinga VOIJNITS, Tanja WALDMANN, Liang ZHAO, Helena T. HOGBERG, Erwin VAN VLIET, 2014. Application of “Omics” Technologies to In Vitro Toxicology. In: ANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York: Springer, 2014, pp. 399-432. Methods in Pharmacology and Toxicology. 1557-2153. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18BibTex
@incollection{Stiegler2014Appli-30151, year={2014}, doi={10.1007/978-1-4939-0521-8_18}, title={Application of “Omics” Technologies to In Vitro Toxicology}, number={1557-2153}, isbn={978-1-4939-0520-1}, publisher={Springer}, address={New York}, series={Methods in Pharmacology and Toxicology}, booktitle={In Vitro Toxicology Systems}, pages={399--432}, editor={Anna Bal-Price ...}, author={Stiegler, Nina and Dao, Tyna and Leist, Marcel and Voijnits, Kinga and Waldmann, Tanja and Zhao, Liang and Hogberg, Helena T. and van Vliet, Erwin} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/30151"> <dcterms:title>Application of “Omics” Technologies to In Vitro Toxicology</dcterms:title> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:creator>Zhao, Liang</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-03-04T11:00:47Z</dcterms:available> <dc:creator>van Vliet, Erwin</dc:creator> <dc:contributor>Dao, Tyna</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:creator>Voijnits, Kinga</dc:creator> <dcterms:issued>2014</dcterms:issued> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dc:creator>Leist, Marcel</dc:creator> <dc:creator>Dao, Tyna</dc:creator> <dc:creator>Stiegler, Nina</dc:creator> <dc:contributor>Stiegler, Nina</dc:contributor> <dc:contributor>Hogberg, Helena T.</dc:contributor> <dcterms:abstract xml:lang="eng">“Omics” technologies have facilitated significant advances in the understanding of toxicity mechanisms in complex biological systems. In this chapter we discuss the most important “omics” technologies and how they are currently applied in the field of in vitro toxicology. For each technology, advantages, limitations, and developmental needs are addressed. In addition, we provide some future prospects on the role of “omics” technologies in the emerging new paradigm of mechanistic toxicity studies. It becomes clear that technological developments have enhanced the application of “omics” technologies in toxicology and simplified the interpretation of the generated information; nevertheless, significant challenges remain to incorporate “omics” technologies and “omics” data in the regulatory decision making process.</dcterms:abstract> <dc:creator>Hogberg, Helena T.</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Waldmann, Tanja</dc:contributor> <dc:creator>Waldmann, Tanja</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>van Vliet, Erwin</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-03-04T11:00:47Z</dc:date> <dc:contributor>Voijnits, Kinga</dc:contributor> <dc:contributor>Leist, Marcel</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/30151"/> <dc:contributor>Zhao, Liang</dc:contributor> </rdf:Description> </rdf:RDF>