Application of “Omics” Technologies to In Vitro Toxicology

Stiegler, Nina; Dao, Tyna; Leist, Marcel; Voijnits, Kinga; Waldmann, Tanja; Zhao, Liang; Hogberg, Helena T.; van Vliet, Erwin

Application of “Omics” Technologies to In Vitro Toxicology

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Date

2014

Authors

Stiegler, Nina

Dao, Tyna

Leist, Marcel

Voijnits, Kinga

Waldmann, Tanja

Zhao, Liang

Hogberg, Helena T.

van Vliet, Erwin

DOI (citable link)

10.1007/978-1-4939-0521-8_18

Collections

Biologie

Publication type

Contribution to a collection

Published in

In Vitro Toxicology Systems / Anna Bal-Price ... (ed.). - New York : Springer, 2014. - (Methods in Pharmacology and Toxicology ; 1557-2153). - pp. 399-432. - ISBN 978-1-4939-0520-1

Abstract

“Omics” technologies have facilitated significant advances in the understanding of toxicity mechanisms in complex biological systems. In this chapter we discuss the most important “omics” technologies and how they are currently applied in the field of in vitro toxicology. For each technology, advantages, limitations, and developmental needs are addressed. In addition, we provide some future prospects on the role of “omics” technologies in the emerging new paradigm of mechanistic toxicity studies. It becomes clear that technological developments have enhanced the application of “omics” technologies in toxicology and simplified the interpretation of the generated information; nevertheless, significant challenges remain to incorporate “omics” technologies and “omics” data in the regulatory decision making process.

Subject (DDC)

570 Biosciences, Biology

Keywords

Transcriptomics, Proteomics, Metabolomics, Epigenetics, Systems biology

Cite This

ISO 690

STIEGLER, Nina, Tyna DAO, Marcel LEIST, Kinga VOIJNITS, Tanja WALDMANN, Liang ZHAO, Helena T. HOGBERG, Erwin VAN VLIET, 2014. Application of “Omics” Technologies to In Vitro Toxicology. In: ANNA BAL-PRICE ..., , ed.. In Vitro Toxicology Systems. New York:Springer, pp. 399-432. ISBN 978-1-4939-0520-1. Available under: doi: 10.1007/978-1-4939-0521-8_18

BibTex

@incollection{Stiegler2014Appli-30151,
  year={2014},
  doi={10.1007/978-1-4939-0521-8_18},
  title={Application of “Omics” Technologies to In Vitro Toxicology},
  number={1557-2153},
  isbn={978-1-4939-0520-1},
  publisher={Springer},
  address={New York},
  series={Methods in Pharmacology and Toxicology},
  booktitle={In Vitro Toxicology Systems},
  pages={399--432},
  editor={Anna Bal-Price ...},
  author={Stiegler, Nina and Dao, Tyna and Leist, Marcel and Voijnits, Kinga and Waldmann, Tanja and Zhao, Liang and Hogberg, Helena T. and van Vliet, Erwin}
}

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Bibliography of Konstanz

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