Inhibiting quinolone biosynthesis of Burkholderia

Kurzanzeige
dc.contributor.authorProthiwa, Michaela
dc.contributor.authorFilz, Verena
dc.contributor.authorOehler, Sebastian
dc.contributor.authorBöttcher, Thomas
dc.date.accessioned2021-04-29T08:52:39Z
dc.date.available2021-04-29T08:52:39Z
dc.date.issued2021-05-26
dc.description.abstract2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibitors quantitatively blocked quinolone production in Burkholderia cultures with single-digit micromolar efficacy.eng
dc.description.versionpublishedde
dc.identifier.doi10.1039/d0sc06167keng
dc.identifier.pmid34123319
dc.identifier.ppn1776449118
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dc.language.isoengeng
dc.rightsAttribution 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subject.ddc540eng
dc.titleInhibiting quinolone biosynthesis of Burkholderiaeng
dc.typeJOURNAL_ARTICLEde
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  doi={10.1039/d0sc06167k},
  title={Inhibiting quinolone biosynthesis of Burkholderia},
  number={20},
  volume={12},
  issn={2041-6520},
  journal={Chemical Science},
  pages={6908--6912},
  author={Prothiwa, Michaela and Filz, Verena and Oehler, Sebastian and Böttcher, Thomas}
}
kops.citation.iso690PROTHIWA, Michaela, Verena FILZ, Sebastian OEHLER, Thomas BÖTTCHER, 2021. Inhibiting quinolone biosynthesis of Burkholderia. In: Chemical Science. Royal Society of Chemistry (RSC). 2021, 12(20), pp. 6908-6912. ISSN 2041-6520. eISSN 2041-6539. Available under: doi: 10.1039/d0sc06167kdeu
kops.citation.iso690PROTHIWA, Michaela, Verena FILZ, Sebastian OEHLER, Thomas BÖTTCHER, 2021. Inhibiting quinolone biosynthesis of Burkholderia. In: Chemical Science. Royal Society of Chemistry (RSC). 2021, 12(20), pp. 6908-6912. ISSN 2041-6520. eISSN 2041-6539. Available under: doi: 10.1039/d0sc06167keng
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