Inhibiting quinolone biosynthesis of Burkholderia

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Prothiwa_2-q64yr1a20cb54.pdf
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2021
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Prothiwa, Michaela
Oehler, Sebastian
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Chemical Science. Royal Society of Chemistry (RSC). 2021, 12(20), pp. 6908-6912. ISSN 2041-6520. eISSN 2041-6539. Available under: doi: 10.1039/d0sc06167k
Zusammenfassung

2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibitors quantitatively blocked quinolone production in Burkholderia cultures with single-digit micromolar efficacy.

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ISO 690PROTHIWA, Michaela, Verena FILZ, Sebastian OEHLER, Thomas BÖTTCHER, 2021. Inhibiting quinolone biosynthesis of Burkholderia. In: Chemical Science. Royal Society of Chemistry (RSC). 2021, 12(20), pp. 6908-6912. ISSN 2041-6520. eISSN 2041-6539. Available under: doi: 10.1039/d0sc06167k
BibTex
@article{Prothiwa2021-05-26Inhib-53527,
  year={2021},
  doi={10.1039/d0sc06167k},
  title={Inhibiting quinolone biosynthesis of Burkholderia},
  number={20},
  volume={12},
  issn={2041-6520},
  journal={Chemical Science},
  pages={6908--6912},
  author={Prothiwa, Michaela and Filz, Verena and Oehler, Sebastian and Böttcher, Thomas}
}
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