Inhibiting quinolone biosynthesis of Burkholderia

Prothiwa, Michaela; Filz, Verena; Oehler, Sebastian; Böttcher, Thomas

Inhibiting quinolone biosynthesis of Burkholderia

Dateien

Prothiwa_2-q64yr1a20cb54.pdfGröße: 1.1 MBDownloads: 59

Datum

2021

Autor:innen

Prothiwa, Michaela

Filz, Verena

Oehler, Sebastian

Böttcher, Thomas

Angaben zur Forschungsförderung

European Union (EU): 291784

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Chemical Science. Royal Society of Chemistry (RSC). 2021, 12(20), pp. 6908-6912. ISSN 2041-6520. eISSN 2041-6539. Available under: doi: 10.1039/d0sc06167k

Zusammenfassung

2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibitors quantitatively blocked quinolone production in Burkholderia cultures with single-digit micromolar efficacy.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

PROTHIWA, Michaela, Verena FILZ, Sebastian OEHLER, Thomas BÖTTCHER, 2021. Inhibiting quinolone biosynthesis of Burkholderia. In: Chemical Science. Royal Society of Chemistry (RSC). 2021, 12(20), pp. 6908-6912. ISSN 2041-6520. eISSN 2041-6539. Available under: doi: 10.1039/d0sc06167k

BibTex

@article{Prothiwa2021-05-26Inhib-53527,
  year={2021},
  doi={10.1039/d0sc06167k},
  title={Inhibiting quinolone biosynthesis of Burkholderia},
  number={20},
  volume={12},
  issn={2041-6520},
  journal={Chemical Science},
  pages={6908--6912},
  author={Prothiwa, Michaela and Filz, Verena and Oehler, Sebastian and Böttcher, Thomas}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/53527">
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/3.0/"/>
    <dc:creator>Oehler, Sebastian</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-04-29T08:52:39Z</dc:date>
    <dc:creator>Böttcher, Thomas</dc:creator>
    <dc:rights>Attribution 3.0 Unported</dc:rights>
    <dc:creator>Filz, Verena</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Prothiwa, Michaela</dc:creator>
    <dcterms:title>Inhibiting quinolone biosynthesis of Burkholderia</dcterms:title>
    <dcterms:issued>2021-05-26</dcterms:issued>
    <dc:contributor>Oehler, Sebastian</dc:contributor>
    <dcterms:abstract xml:lang="eng">2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibitors quantitatively blocked quinolone production in Burkholderia cultures with single-digit micromolar efficacy.</dcterms:abstract>
    <dc:contributor>Filz, Verena</dc:contributor>
    <dc:contributor>Prothiwa, Michaela</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:contributor>Böttcher, Thomas</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-04-29T08:52:39Z</dcterms:available>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/53527"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/53527/1/Prothiwa_2-q64yr1a20cb54.pdf"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/53527/1/Prothiwa_2-q64yr1a20cb54.pdf"/>
    <dc:language>eng</dc:language>
  </rdf:Description>
</rdf:RDF>

Universitätsbibliographie

Ja

Begutachtet

Ja