A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals

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dc.contributor.authorMisiak, Błażej
dc.contributor.authorPruessner, Marita
dc.contributor.authorSamochowiec, Jerzy
dc.contributor.authorWiśniewski, Michał
dc.contributor.authorReginia, Artur
dc.contributor.authorStańczykiewicz, Bartłomiej
dc.date.accessioned2021-10-29T07:48:15Z
dc.date.available2021-10-29T07:48:15Z
dc.date.issued2021eng
dc.description.abstractDysregulated cortisol responses and glucose metabolism have been reported in psychosis. We performed a random-effects meta-analysis of cortisol responses in first-episode psychosis (FEP) and psychosis risk states, taking into consideration glucose metabolism. A total of 47 studies were included. Unstimulated blood cortisol levels were significantly higher (g = 0.48, 95 %CI: 0.25–0.70, p < 0.001) in FEP, but not in psychosis risk states (g = 0.39, 95 %CI: −0.42–1.21, p = 0.342), compared to controls. Cortisol awakening response (CAR) was attenuated in FEP (g = −0.40, 95 %CI: −0.68 - −0.12, p = 0.006), but not in psychosis risk states (p = 0.433). Glucose and insulin levels were positively correlated with unstimulated blood cortisol levels in FEP. Our meta-analysis supports previous findings of elevated blood cortisol levels and attenuated CAR in FEP. Future research should focus on identifying the common denominators for alterations in stress hormones and glucose metabolism.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1016/j.yfrne.2021.100930eng
dc.identifier.pmid34171354eng
dc.identifier.ppn1775702138
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/55410
dc.language.isoengeng
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHPA axis; Schizophrenia; Stress; Psychosis risk; Early interventioneng
dc.subject.ddc150eng
dc.titleA meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individualseng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Misiak2021metaa-55410,
  year={2021},
  doi={10.1016/j.yfrne.2021.100930},
  title={A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals},
  volume={62},
  issn={0091-3022},
  journal={Frontiers in Neuroendocrinology},
  author={Misiak, Błażej and Pruessner, Marita and Samochowiec, Jerzy and Wiśniewski, Michał and Reginia, Artur and Stańczykiewicz, Bartłomiej},
  note={Article Number: 100930}
}
kops.citation.iso690MISIAK, Błażej, Marita PRUESSNER, Jerzy SAMOCHOWIEC, Michał WIŚNIEWSKI, Artur REGINIA, Bartłomiej STAŃCZYKIEWICZ, 2021. A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals. In: Frontiers in Neuroendocrinology. Elsevier. 2021, 62, 100930. ISSN 0091-3022. eISSN 1095-6808. Available under: doi: 10.1016/j.yfrne.2021.100930deu
kops.citation.iso690MISIAK, Błażej, Marita PRUESSNER, Jerzy SAMOCHOWIEC, Michał WIŚNIEWSKI, Artur REGINIA, Bartłomiej STAŃCZYKIEWICZ, 2021. A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals. In: Frontiers in Neuroendocrinology. Elsevier. 2021, 62, 100930. ISSN 0091-3022. eISSN 1095-6808. Available under: doi: 10.1016/j.yfrne.2021.100930eng
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