A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals

Misiak, Błażej; Pruessner, Marita; Samochowiec, Jerzy; Wiśniewski, Michał; Reginia, Artur; Stańczykiewicz, Bartłomiej

A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals

Dateien

Misiak_2-q7aeqs3awn211.pdfGröße: 1.15 MBDownloads: 216

Datum

2021

Autor:innen

Misiak, Błażej

Pruessner, Marita

Samochowiec, Jerzy

Wiśniewski, Michał

Reginia, Artur

Stańczykiewicz, Bartłomiej

Open Access-Veröffentlichung

Open Access Hybrid

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Frontiers in Neuroendocrinology. Elsevier. 2021, 62, 100930. ISSN 0091-3022. eISSN 1095-6808. Available under: doi: 10.1016/j.yfrne.2021.100930

Zusammenfassung

Dysregulated cortisol responses and glucose metabolism have been reported in psychosis. We performed a random-effects meta-analysis of cortisol responses in first-episode psychosis (FEP) and psychosis risk states, taking into consideration glucose metabolism. A total of 47 studies were included. Unstimulated blood cortisol levels were significantly higher (g = 0.48, 95 %CI: 0.25–0.70, p < 0.001) in FEP, but not in psychosis risk states (g = 0.39, 95 %CI: −0.42–1.21, p = 0.342), compared to controls. Cortisol awakening response (CAR) was attenuated in FEP (g = −0.40, 95 %CI: −0.68 - −0.12, p = 0.006), but not in psychosis risk states (p = 0.433). Glucose and insulin levels were positively correlated with unstimulated blood cortisol levels in FEP. Our meta-analysis supports previous findings of elevated blood cortisol levels and attenuated CAR in FEP. Future research should focus on identifying the common denominators for alterations in stress hormones and glucose metabolism.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

HPA axis; Schizophrenia; Stress; Psychosis risk; Early intervention

Zitieren

ISO 690

MISIAK, Błażej, Marita PRUESSNER, Jerzy SAMOCHOWIEC, Michał WIŚNIEWSKI, Artur REGINIA, Bartłomiej STAŃCZYKIEWICZ, 2021. A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals. In: Frontiers in Neuroendocrinology. Elsevier. 2021, 62, 100930. ISSN 0091-3022. eISSN 1095-6808. Available under: doi: 10.1016/j.yfrne.2021.100930

BibTex

@article{Misiak2021metaa-55410,
  year={2021},
  doi={10.1016/j.yfrne.2021.100930},
  title={A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals},
  volume={62},
  issn={0091-3022},
  journal={Frontiers in Neuroendocrinology},
  author={Misiak, Błażej and Pruessner, Marita and Samochowiec, Jerzy and Wiśniewski, Michał and Reginia, Artur and Stańczykiewicz, Bartłomiej},
  note={Article Number: 100930}
}

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