Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2013
Autor:innen
Yoon, Je-Hyun
Abdelmohsen, Kotb
Kim, Jiyoung
Yang, Xiaoling
Martindale, Jennifer L.
Tominaga-Yamanaka, Kumiko
White, Elizabeth J.
Orjalo, Arturo V.
Rinn, John L.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Gold
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Nature Communications. 2013, 4, 2939. eISSN 2041-1723. Available under: doi: 10.1038/ncomms3939
Zusammenfassung

Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence. These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690YOON, Je-Hyun, Kotb ABDELMOHSEN, Jiyoung KIM, Xiaoling YANG, Jennifer L. MARTINDALE, Kumiko TOMINAGA-YAMANAKA, Elizabeth J. WHITE, Arturo V. ORJALO, John L. RINN, Stefan G. KREFT, Gerald M. WILSON, Myriam GOROSPE, 2013. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. In: Nature Communications. 2013, 4, 2939. eISSN 2041-1723. Available under: doi: 10.1038/ncomms3939
BibTex
@article{Yoon2013Scaff-26044,
  year={2013},
  doi={10.1038/ncomms3939},
  title={Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination},
  volume={4},
  journal={Nature Communications},
  author={Yoon, Je-Hyun and Abdelmohsen, Kotb and Kim, Jiyoung and Yang, Xiaoling and Martindale, Jennifer L. and Tominaga-Yamanaka, Kumiko and White, Elizabeth J. and Orjalo, Arturo V. and Rinn, John L. and Kreft, Stefan G. and Wilson, Gerald M. and Gorospe, Myriam},
  note={Article Number: 2939}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/26044">
    <dc:contributor>Martindale, Jennifer L.</dc:contributor>
    <dc:contributor>Orjalo, Arturo V.</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-24T07:38:54Z</dc:date>
    <dc:contributor>Yang, Xiaoling</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/26044"/>
    <dc:creator>Rinn, John L.</dc:creator>
    <dcterms:abstract xml:lang="eng">Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence. These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination.</dcterms:abstract>
    <dcterms:bibliographicCitation>Nature Communications ; 4 (2013). - 2939</dcterms:bibliographicCitation>
    <dc:creator>Kreft, Stefan G.</dc:creator>
    <dc:creator>White, Elizabeth J.</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Abdelmohsen, Kotb</dc:contributor>
    <dc:creator>Tominaga-Yamanaka, Kumiko</dc:creator>
    <dc:contributor>Yoon, Je-Hyun</dc:contributor>
    <dc:contributor>White, Elizabeth J.</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-24T07:38:54Z</dcterms:available>
    <dcterms:issued>2013</dcterms:issued>
    <dc:creator>Gorospe, Myriam</dc:creator>
    <dc:creator>Yang, Xiaoling</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Abdelmohsen, Kotb</dc:creator>
    <dc:contributor>Rinn, John L.</dc:contributor>
    <dc:creator>Yoon, Je-Hyun</dc:creator>
    <dc:language>eng</dc:language>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/26044/2/Yoon_260444.pdf"/>
    <dc:creator>Wilson, Gerald M.</dc:creator>
    <dc:creator>Kim, Jiyoung</dc:creator>
    <dc:contributor>Wilson, Gerald M.</dc:contributor>
    <dc:contributor>Gorospe, Myriam</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/26044/2/Yoon_260444.pdf"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Kim, Jiyoung</dc:contributor>
    <dc:contributor>Kreft, Stefan G.</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Orjalo, Arturo V.</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:title>Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination</dcterms:title>
    <dc:creator>Martindale, Jennifer L.</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Tominaga-Yamanaka, Kumiko</dc:contributor>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen