Publikation:

Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination

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Yoon_260444.pdf
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2013

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Yoon, Je-Hyun
Abdelmohsen, Kotb
Kim, Jiyoung
Yang, Xiaoling
Martindale, Jennifer L.
Tominaga-Yamanaka, Kumiko
White, Elizabeth J.
Orjalo, Arturo V.
Rinn, John L.
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http://nbn-resolving.de/urn:nbn:de:bsz:352-260444
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https://doi.org/10.1038/ncomms3939
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Nature Communications. 2013, 4, 2939. eISSN 2041-1723. Available under: doi: 10.1038/ncomms3939

Zusammenfassung

Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence. These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination.

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570 Biowissenschaften, Biologie

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ISO 690YOON, Je-Hyun, Kotb ABDELMOHSEN, Jiyoung KIM, Xiaoling YANG, Jennifer L. MARTINDALE, Kumiko TOMINAGA-YAMANAKA, Elizabeth J. WHITE, Arturo V. ORJALO, John L. RINN, Stefan G. KREFT, Gerald M. WILSON, Myriam GOROSPE, 2013. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. In: Nature Communications. 2013, 4, 2939. eISSN 2041-1723. Available under: doi: 10.1038/ncomms3939
BibTex
@article{Yoon2013Scaff-26044,
  year={2013},
  doi={10.1038/ncomms3939},
  title={Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination},
  volume={4},
  journal={Nature Communications},
  author={Yoon, Je-Hyun and Abdelmohsen, Kotb and Kim, Jiyoung and Yang, Xiaoling and Martindale, Jennifer L. and Tominaga-Yamanaka, Kumiko and White, Elizabeth J. and Orjalo, Arturo V. and Rinn, John L. and Kreft, Stefan G. and Wilson, Gerald M. and Gorospe, Myriam},
  note={Article Number: 2939}
}
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