Publikation:

Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination

Vorschaubild

Dateien

Yoon_260444.pdf
Yoon_260444.pdfGröße: 4.11 MBDownloads: 628

Datum

2013

Autor:innen

Yoon, Je-Hyun
Abdelmohsen, Kotb
Kim, Jiyoung
Yang, Xiaoling
Martindale, Jennifer L.
Tominaga-Yamanaka, Kumiko
White, Elizabeth J.
Orjalo, Arturo V.
Rinn, John L.
2 mehr anzeigen

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-260444
DOI (zitierfähiger Link)
https://doi.org/10.1038/ncomms3939
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Urheberrechtlich geschützt

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Gold

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Nature Communications. 2013, 4, 2939. eISSN 2041-1723. Available under: doi: 10.1038/ncomms3939

Zusammenfassung

Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence. These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Verknüpfte Datensätze

Zitieren

ISO 690YOON, Je-Hyun, Kotb ABDELMOHSEN, Jiyoung KIM, Xiaoling YANG, Jennifer L. MARTINDALE, Kumiko TOMINAGA-YAMANAKA, Elizabeth J. WHITE, Arturo V. ORJALO, John L. RINN, Stefan G. KREFT, Gerald M. WILSON, Myriam GOROSPE, 2013. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. In: Nature Communications. 2013, 4, 2939. eISSN 2041-1723. Available under: doi: 10.1038/ncomms3939
BibTex
@article{Yoon2013Scaff-26044,
  year={2013},
  doi={10.1038/ncomms3939},
  title={Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination},
  volume={4},
  journal={Nature Communications},
  author={Yoon, Je-Hyun and Abdelmohsen, Kotb and Kim, Jiyoung and Yang, Xiaoling and Martindale, Jennifer L. and Tominaga-Yamanaka, Kumiko and White, Elizabeth J. and Orjalo, Arturo V. and Rinn, John L. and Kreft, Stefan G. and Wilson, Gerald M. and Gorospe, Myriam},
  note={Article Number: 2939}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/26044">
    <dc:contributor>Martindale, Jennifer L.</dc:contributor>
    <dc:contributor>Orjalo, Arturo V.</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-24T07:38:54Z</dc:date>
    <dc:contributor>Yang, Xiaoling</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/26044"/>
    <dc:creator>Rinn, John L.</dc:creator>
    <dcterms:abstract xml:lang="eng">Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence. These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination.</dcterms:abstract>
    <dcterms:bibliographicCitation>Nature Communications ; 4 (2013). - 2939</dcterms:bibliographicCitation>
    <dc:creator>Kreft, Stefan G.</dc:creator>
    <dc:creator>White, Elizabeth J.</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Abdelmohsen, Kotb</dc:contributor>
    <dc:creator>Tominaga-Yamanaka, Kumiko</dc:creator>
    <dc:contributor>Yoon, Je-Hyun</dc:contributor>
    <dc:contributor>White, Elizabeth J.</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-24T07:38:54Z</dcterms:available>
    <dcterms:issued>2013</dcterms:issued>
    <dc:creator>Gorospe, Myriam</dc:creator>
    <dc:creator>Yang, Xiaoling</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Abdelmohsen, Kotb</dc:creator>
    <dc:contributor>Rinn, John L.</dc:contributor>
    <dc:creator>Yoon, Je-Hyun</dc:creator>
    <dc:language>eng</dc:language>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/26044/2/Yoon_260444.pdf"/>
    <dc:creator>Wilson, Gerald M.</dc:creator>
    <dc:creator>Kim, Jiyoung</dc:creator>
    <dc:contributor>Wilson, Gerald M.</dc:contributor>
    <dc:contributor>Gorospe, Myriam</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/26044/2/Yoon_260444.pdf"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Kim, Jiyoung</dc:contributor>
    <dc:contributor>Kreft, Stefan G.</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Orjalo, Arturo V.</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:title>Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination</dcterms:title>
    <dc:creator>Martindale, Jennifer L.</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Tominaga-Yamanaka, Kumiko</dc:contributor>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen