Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity

Kurzanzeige
dc.contributor.authorDebiak, Malgorzata
dc.contributor.authorKehe, Kaideu
dc.contributor.authorBürkle, Alexander
dc.date.accessioned2011-03-24T17:43:10Zdeu
dc.date.available2011-03-24T17:43:10Zdeu
dc.date.issued2009deu
dc.description.abstractSulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury.eng
dc.description.versionpublished
dc.format.mimetypeapplication/pdfdeu
dc.identifier.citationFirst publ. in: Toxicology 263 (2009), 1, pp. 20-25deu
dc.identifier.doi10.1016/j.tox.2008.06.002
dc.identifier.pmid18602966
dc.identifier.ppn311120717deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/8382
dc.language.isoengdeu
dc.legacy.dateIssued2009deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectSulfur mustarddeu
dc.subjectPARPdeu
dc.subjectDNA repairdeu
dc.subjectCell deathdeu
dc.subjectNAD+deu
dc.subject3-Aminobenzamidedeu
dc.subject.ddc570deu
dc.titleRole of poly(ADP-ribose) polymerase in sulfur mustard toxicityeng
dc.typeJOURNAL_ARTICLEdeu
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@article{Debiak2009polyA-8382,
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  doi={10.1016/j.tox.2008.06.002},
  title={Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity},
  number={1},
  volume={263},
  issn={0300-483X},
  journal={Toxicology},
  pages={20--25},
  author={Debiak, Malgorzata and Kehe, Kai and Bürkle, Alexander}
}
kops.citation.iso690DEBIAK, Malgorzata, Kai KEHE, Alexander BÜRKLE, 2009. Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity. In: Toxicology. 2009, 263(1), pp. 20-25. ISSN 0300-483X. eISSN 1879-3185. Available under: doi: 10.1016/j.tox.2008.06.002deu
kops.citation.iso690DEBIAK, Malgorzata, Kai KEHE, Alexander BÜRKLE, 2009. Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity. In: Toxicology. 2009, 263(1), pp. 20-25. ISSN 0300-483X. eISSN 1879-3185. Available under: doi: 10.1016/j.tox.2008.06.002eng
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