Publikation:

Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity

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2008_Toxicology_epub_Debiak.pdf
2008_Toxicology_epub_Debiak.pdfGröße: 541.79 KBDownloads: 565

Datum

2009

Autor:innen

Kehe, Kai

Herausgeber:innen

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ISBN

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-77478
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.tox.2008.06.002
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Urheberrechtlich geschützt

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Open Access-Veröffentlichung
Open Access Green

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Toxicology. 2009, 263(1), pp. 20-25. ISSN 0300-483X. eISSN 1879-3185. Available under: doi: 10.1016/j.tox.2008.06.002

Zusammenfassung

Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Sulfur mustard, PARP, DNA repair, Cell death, NAD+, 3-Aminobenzamide

Konferenz

Rezension
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ISO 690DEBIAK, Malgorzata, Kai KEHE, Alexander BÜRKLE, 2009. Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity. In: Toxicology. 2009, 263(1), pp. 20-25. ISSN 0300-483X. eISSN 1879-3185. Available under: doi: 10.1016/j.tox.2008.06.002
BibTex
@article{Debiak2009polyA-8382,
  year={2009},
  doi={10.1016/j.tox.2008.06.002},
  title={Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity},
  number={1},
  volume={263},
  issn={0300-483X},
  journal={Toxicology},
  pages={20--25},
  author={Debiak, Malgorzata and Kehe, Kai and Bürkle, Alexander}
}
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