Biodegradable Core–Multishell Nanocarriers : Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

Kurzanzeige
dc.contributor.authorUnbehauen, Michael L.
dc.contributor.authorFleige, Emanuel
dc.contributor.authorPaulus, Florian
dc.contributor.authorSchemmer, Brigitta
dc.contributor.authorMecking, Stefan
dc.contributor.authorMoré, Sam Dylan
dc.contributor.authorHaag, Rainer
dc.date.accessioned2017-10-13T09:00:15Z
dc.date.available2017-10-13T09:00:15Z
dc.date.issued2017-08eng
dc.description.abstractWe here present the synthesis and characterization of a set of biodegradable core–multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12, 15, 18, 19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery.eng
dc.description.versionpublishedde
dc.identifier.doi10.3390/polym9080316eng
dc.identifier.ppn494382724
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/40329
dc.language.isoengeng
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbiodegradable CMS nanocarrier; drug delivery; dendritic polymers; dexamethasone; tacrolimuseng
dc.subject.ddc540eng
dc.titleBiodegradable Core–Multishell Nanocarriers : Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimuseng
dc.typeJOURNAL_ARTICLEde
dspace.entity.typePublication
kops.citation.bibtex
@article{Unbehauen2017-08Biode-40329,
  year={2017},
  doi={10.3390/polym9080316},
  title={Biodegradable Core–Multishell Nanocarriers : Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus},
  number={8},
  volume={9},
  journal={Polymers},
  author={Unbehauen, Michael L. and Fleige, Emanuel and Paulus, Florian and Schemmer, Brigitta and Mecking, Stefan and Moré, Sam Dylan and Haag, Rainer},
  note={Article Number: 316}
}
kops.citation.iso690UNBEHAUEN, Michael L., Emanuel FLEIGE, Florian PAULUS, Brigitta SCHEMMER, Stefan MECKING, Sam Dylan MORÉ, Rainer HAAG, 2017. Biodegradable Core–Multishell Nanocarriers : Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus. In: Polymers. 2017, 9(8), 316. eISSN 2073-4360. Available under: doi: 10.3390/polym9080316deu
kops.citation.iso690UNBEHAUEN, Michael L., Emanuel FLEIGE, Florian PAULUS, Brigitta SCHEMMER, Stefan MECKING, Sam Dylan MORÉ, Rainer HAAG, 2017. Biodegradable Core–Multishell Nanocarriers : Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus. In: Polymers. 2017, 9(8), 316. eISSN 2073-4360. Available under: doi: 10.3390/polym9080316eng
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