Publikation:

Biodegradable Core–Multishell Nanocarriers : Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

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Datum

2017

Autor:innen

Unbehauen, Michael L.
Fleige, Emanuel
Paulus, Florian
Moré, Sam Dylan
Haag, Rainer

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http://nbn-resolving.de/urn:nbn:de:bsz:352-1-bad8e7304e2b494a6
DOI (zitierfähiger Link)
https://doi.org/10.3390/polym9080316
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Chemie: Publikationen
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Published

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Polymers. 2017, 9(8), 316. eISSN 2073-4360. Available under: doi: 10.3390/polym9080316

Zusammenfassung

We here present the synthesis and characterization of a set of biodegradable core–multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12, 15, 18, 19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

biodegradable CMS nanocarrier; drug delivery; dendritic polymers; dexamethasone; tacrolimus

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ISO 690UNBEHAUEN, Michael L., Emanuel FLEIGE, Florian PAULUS, Brigitta SCHEMMER, Stefan MECKING, Sam Dylan MORÉ, Rainer HAAG, 2017. Biodegradable Core–Multishell Nanocarriers : Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus. In: Polymers. 2017, 9(8), 316. eISSN 2073-4360. Available under: doi: 10.3390/polym9080316
BibTex
@article{Unbehauen2017-08Biode-40329,
  year={2017},
  doi={10.3390/polym9080316},
  title={Biodegradable Core–Multishell Nanocarriers : Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus},
  number={8},
  volume={9},
  journal={Polymers},
  author={Unbehauen, Michael L. and Fleige, Emanuel and Paulus, Florian and Schemmer, Brigitta and Mecking, Stefan and Moré, Sam Dylan and Haag, Rainer},
  note={Article Number: 316}
}
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