Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader

Kurzanzeige
dc.contributor.authorLee, Yan-Jiun
dc.contributor.authorSchmidt, Moritz J.
dc.contributor.authorTharp, Jeffery M.
dc.contributor.authorWeber, Annemarie
dc.contributor.authorKoenig, Amber L.
dc.contributor.authorZheng, Hong
dc.contributor.authorGao, Jianmin
dc.contributor.authorWaters, Marcey L.
dc.contributor.authorSummerer, Daniel
dc.contributor.authorLiu, Wenshe R.
dc.date.accessioned2017-02-22T11:40:22Z
dc.date.available2017-02-22T11:40:22Z
dc.date.issued2016eng
dc.description.abstractFluorophenylalanines bearing 2-5 fluorine atoms at the phenyl ring have been genetically encoded by amber codon. Replacement of F59, a phenylalanine residue that is directly involved in interactions with trimethylated K9 of histone H3, in the Mpp8 chromodomain recombinantly with fluorophenylalanines significantly impairs the binding to a K9-trimethylated H3 peptide.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1039/c6cc05959geng
dc.identifier.pmid27711380eng
dc.identifier.ppn486925870
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/37676
dc.language.isoengeng
dc.rightsAttribution 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subject.ddc540eng
dc.titleGenetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic readereng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Lee2016Genet-37676,
  year={2016},
  doi={10.1039/c6cc05959g},
  title={Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader},
  number={85},
  volume={52},
  issn={0009-241X},
  journal={Chemical Communications : ChemComm},
  pages={12606--12609},
  author={Lee, Yan-Jiun and Schmidt, Moritz J. and Tharp, Jeffery M. and Weber, Annemarie and Koenig, Amber L. and Zheng, Hong and Gao, Jianmin and Waters, Marcey L. and Summerer, Daniel and Liu, Wenshe R.}
}
kops.citation.iso690LEE, Yan-Jiun, Moritz J. SCHMIDT, Jeffery M. THARP, Annemarie WEBER, Amber L. KOENIG, Hong ZHENG, Jianmin GAO, Marcey L. WATERS, Daniel SUMMERER, Wenshe R. LIU, 2016. Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader. In: Chemical Communications : ChemComm. 2016, 52(85), pp. 12606-12609. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/c6cc05959gdeu
kops.citation.iso690LEE, Yan-Jiun, Moritz J. SCHMIDT, Jeffery M. THARP, Annemarie WEBER, Amber L. KOENIG, Hong ZHENG, Jianmin GAO, Marcey L. WATERS, Daniel SUMMERER, Wenshe R. LIU, 2016. Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader. In: Chemical Communications : ChemComm. 2016, 52(85), pp. 12606-12609. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/c6cc05959geng
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kops.sourcefield.plainChemical Communications : ChemComm. 2016, 52(85), pp. 12606-12609. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/c6cc05959geng
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