Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader

Lade...
Vorschaubild
Dateien
Lee_0-374553.pdf
Lee_0-374553.pdfGröße: 1.96 MBDownloads: 297
Datum
2016
Autor:innen
Lee, Yan-Jiun
Tharp, Jeffery M.
Koenig, Amber L.
Gao, Jianmin
Waters, Marcey L.
Liu, Wenshe R.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Hybrid
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Zusammenfassung

Fluorophenylalanines bearing 2-5 fluorine atoms at the phenyl ring have been genetically encoded by amber codon. Replacement of F59, a phenylalanine residue that is directly involved in interactions with trimethylated K9 of histone H3, in the Mpp8 chromodomain recombinantly with fluorophenylalanines significantly impairs the binding to a K9-trimethylated H3 peptide.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690LEE, Yan-Jiun, Moritz J. SCHMIDT, Jeffery M. THARP, Annemarie WEBER, Amber L. KOENIG, Hong ZHENG, Jianmin GAO, Marcey L. WATERS, Daniel SUMMERER, Wenshe R. LIU, 2016. Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader. In: Chemical Communications : ChemComm. 2016, 52(85), pp. 12606-12609. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/c6cc05959g
BibTex
@article{Lee2016Genet-37676,
  year={2016},
  doi={10.1039/c6cc05959g},
  title={Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader},
  number={85},
  volume={52},
  issn={0009-241X},
  journal={Chemical Communications : ChemComm},
  pages={12606--12609},
  author={Lee, Yan-Jiun and Schmidt, Moritz J. and Tharp, Jeffery M. and Weber, Annemarie and Koenig, Amber L. and Zheng, Hong and Gao, Jianmin and Waters, Marcey L. and Summerer, Daniel and Liu, Wenshe R.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/37676">
    <dc:creator>Koenig, Amber L.</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/3.0/"/>
    <dc:rights>Attribution 3.0 Unported</dc:rights>
    <dc:contributor>Gao, Jianmin</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/37676"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/37676/1/Lee_0-374553.pdf"/>
    <dc:contributor>Weber, Annemarie</dc:contributor>
    <dc:contributor>Lee, Yan-Jiun</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Gao, Jianmin</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-22T11:40:22Z</dcterms:available>
    <dc:creator>Weber, Annemarie</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-22T11:40:22Z</dc:date>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/41"/>
    <dc:contributor>Liu, Wenshe R.</dc:contributor>
    <dc:creator>Summerer, Daniel</dc:creator>
    <dc:contributor>Summerer, Daniel</dc:contributor>
    <dcterms:title>Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader</dcterms:title>
    <dc:language>eng</dc:language>
    <dc:creator>Lee, Yan-Jiun</dc:creator>
    <dc:contributor>Koenig, Amber L.</dc:contributor>
    <dc:creator>Zheng, Hong</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/37676/1/Lee_0-374553.pdf"/>
    <dc:creator>Schmidt, Moritz J.</dc:creator>
    <dc:contributor>Schmidt, Moritz J.</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/41"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:creator>Liu, Wenshe R.</dc:creator>
    <dc:creator>Tharp, Jeffery M.</dc:creator>
    <dc:creator>Waters, Marcey L.</dc:creator>
    <dcterms:abstract xml:lang="eng">Fluorophenylalanines bearing 2-5 fluorine atoms at the phenyl ring have been genetically encoded by amber codon. Replacement of F59, a phenylalanine residue that is directly involved in interactions with trimethylated K9 of histone H3, in the Mpp8 chromodomain recombinantly with fluorophenylalanines significantly impairs the binding to a K9-trimethylated H3 peptide.</dcterms:abstract>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dcterms:issued>2016</dcterms:issued>
    <dc:contributor>Zheng, Hong</dc:contributor>
    <dc:contributor>Waters, Marcey L.</dc:contributor>
    <dc:contributor>Tharp, Jeffery M.</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen