Genetic risk for schizophrenia impacts Theory-of-Mind-related brain activation

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dc.contributor.authorWalter, Henrik
dc.contributor.authorSchnell, Knut
dc.contributor.authorErk, Susanne
dc.contributor.authorArnold, Claudia
dc.contributor.authorKirsch, Peter
dc.contributor.authorEsslinger, Christine
dc.contributor.authorMier, Daniela
dc.contributor.authorSchmitgen, Mike M.
dc.contributor.authorRietschel, Marcella
dc.contributor.authorWitt, Stephanie H.
dc.date.accessioned2022-02-18T10:59:03Z
dc.date.available2022-02-18T10:59:03Z
dc.date.issued2011-04eng
dc.description.abstractProblems with mentalizing, also called Theory of Mind (ToM), are a hallmark of schizophrenia. Here we show that activation during mentalizing of emotions (green) in healthy controls is modulated by a genetic risk variant for psychosis. A frequent functional single-nucleotide polymorphism in an intron of the ZNF804A gene is the first genetic variant that has been found to be associated with schizophrenia and bipolar disorder on a genomewide significance level. Key areas of the ToM-Network (in red) previously found to be hypoactive in schizophrenia show decreasing ToM-specific activation with the number of risk alleles. For more info on this topic, please refer to the article by Walter et al. on pages 462–470.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1038/mp.2011.25eng
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/56598
dc.language.isoengeng
dc.rightsterms-of-use
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dc.subject.ddc150eng
dc.titleGenetic risk for schizophrenia impacts Theory-of-Mind-related brain activationeng
dc.typeOTHER_TEXTeng
dspace.entity.typePublication
kops.citation.bibtex
@misc{Walter2011-04Genet-56598,
  year={2011},
  doi={10.1038/mp.2011.25},
  title={Genetic risk for schizophrenia impacts Theory-of-Mind-related brain activation},
  author={Walter, Henrik and Schnell, Knut and Erk, Susanne and Arnold, Claudia and Kirsch, Peter and Esslinger, Christine and Mier, Daniela and Schmitgen, Mike M. and Rietschel, Marcella and Witt, Stephanie H.},
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}
kops.citation.iso690WALTER, Henrik, Knut SCHNELL, Susanne ERK, Claudia ARNOLD, Peter KIRSCH, Christine ESSLINGER, Daniela MIER, Mike M. SCHMITGEN, Marcella RIETSCHEL, Stephanie H. WITT, 2011. Genetic risk for schizophrenia impacts Theory-of-Mind-related brain activation. In: Molecular Psychiatry, 16. Springer Nature, pp. 353. Available under: doi: 10.1038/mp.2011.25deu
kops.citation.iso690WALTER, Henrik, Knut SCHNELL, Susanne ERK, Claudia ARNOLD, Peter KIRSCH, Christine ESSLINGER, Daniela MIER, Mike M. SCHMITGEN, Marcella RIETSCHEL, Stephanie H. WITT, 2011. Genetic risk for schizophrenia impacts Theory-of-Mind-related brain activation. In: Molecular Psychiatry, 16. Springer Nature, pp. 353. Available under: doi: 10.1038/mp.2011.25eng
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    <dcterms:abstract xml:lang="eng">Problems with mentalizing, also called Theory of Mind (ToM), are a hallmark of schizophrenia. Here we show that activation during mentalizing of emotions (green) in healthy controls is modulated by a genetic risk variant for psychosis. A frequent functional single-nucleotide polymorphism in an intron of the ZNF804A gene is the first genetic variant that has been found to be associated with schizophrenia and bipolar disorder on a genomewide significance level. Key areas of the ToM-Network (in red) previously found to be hypoactive in schizophrenia show decreasing ToM-specific activation with the number of risk alleles. For more info on this topic, please refer to the article by Walter et al. on pages 462–470.</dcterms:abstract>
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kops.sourcefield<i>Molecular Psychiatry, 16</i>. Springer Nature, pp. 353. Available under: doi: 10.1038/mp.2011.25deu
kops.sourcefield.plainMolecular Psychiatry, 16. Springer Nature, pp. 353. Available under: doi: 10.1038/mp.2011.25deu
kops.sourcefield.plainMolecular Psychiatry, 16. Springer Nature, pp. 353. Available under: doi: 10.1038/mp.2011.25eng
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