Publikation: Genetic risk for schizophrenia impacts Theory-of-Mind-related brain activation
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Datum
April 2011
Autor:innen
Walter, Henrik
Schnell, Knut
Erk, Susanne
Arnold, Claudia
Kirsch, Peter
Esslinger, Christine
Schmitgen, Mike M.
Rietschel, Marcella
Witt, Stephanie H.
et al.
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Molecular Psychiatry, 16. Springer Nature, pp. 353. Available under: doi: 10.1038/mp.2011.25
Zusammenfassung
Problems with mentalizing, also called Theory of Mind (ToM), are a hallmark of schizophrenia. Here we show that activation during mentalizing of emotions (green) in healthy controls is modulated by a genetic risk variant for psychosis. A frequent functional single-nucleotide polymorphism in an intron of the ZNF804A gene is the first genetic variant that has been found to be associated with schizophrenia and bipolar disorder on a genomewide significance level. Key areas of the ToM-Network (in red) previously found to be hypoactive in schizophrenia show decreasing ToM-specific activation with the number of risk alleles. For more info on this topic, please refer to the article by Walter et al. on pages 462–470.
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150 Psychologie
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WALTER, Henrik, Knut SCHNELL, Susanne ERK, Claudia ARNOLD, Peter KIRSCH, Christine ESSLINGER, Daniela MIER, Mike M. SCHMITGEN, Marcella RIETSCHEL, Stephanie H. WITT, 2011. Genetic risk for schizophrenia impacts Theory-of-Mind-related brain activation. In: Molecular Psychiatry, 16. Springer Nature, pp. 353. Available under: doi: 10.1038/mp.2011.25BibTex
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title={Genetic risk for schizophrenia impacts Theory-of-Mind-related brain activation},
author={Walter, Henrik and Schnell, Knut and Erk, Susanne and Arnold, Claudia and Kirsch, Peter and Esslinger, Christine and Mier, Daniela and Schmitgen, Mike M. and Rietschel, Marcella and Witt, Stephanie H.},
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