Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish

Kurzanzeige
dc.contributor.authorGibert, Yanndeu
dc.contributor.authorMcMillan, D. Randydeu
dc.contributor.authorKayes-Wandover, Kathleendeu
dc.contributor.authorMeyer, Axel
dc.contributor.authorBegemann, Gerrit
dc.contributor.authorWhite, Perrin C.deu
dc.date.accessioned2011-03-24T17:36:26Zdeu
dc.date.available2011-03-24T17:36:26Zdeu
dc.date.issued2005deu
dc.description.abstractVery Large G-protein coupled Receptor-1 (VLGR1/Mass1/USH2C) is the largest known cell surface protein in vertebrates. Mutations in VLGR1 are associated with audiogenic epilepsy in mice and Usher syndrome (sensorineural deafness and retinitis pigmentosa) in humans. We characterized the zebrafish VLGR1 gene (vlgr1). It is 51% identical to human VLGR1 in amino acid sequence, but is 64% identical in the 7-transmembrane and cytoplasmic domains. It is 6199 amino acids in size and is encoded by a 19.2 kb mRNA. All introns correspond in location and phase to those of the human and mouse genes. In situ hybridization studies of zebrafish embryos demonstrate vlgr1 expression in the developing central nervous system, particularly in the hypothalamus, epiphysis and in the rhombic lips. Expression in the eye is associated with the optic nerve. Further studies using zebrafish may help ascertain the role of Vlgr1 in neural development.eng
dc.description.versionpublished
dc.format.mimetypeapplication/pdfdeu
dc.identifier.citationFirst publ. in: Gene 353 (2005), pp. 200 206deu
dc.identifier.doi10.1016/j.gene.2005.05.015
dc.identifier.pmid15979825
dc.identifier.ppn267498861deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/7692
dc.language.isoengdeu
dc.legacy.dateIssued2007deu
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 Generic
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/
dc.subjectUsher syndromedeu
dc.subjectIn situ hybridizationdeu
dc.subjectDiencephalondeu
dc.subjectOptic nervedeu
dc.subjectZebrafishdeu
dc.subject.ddc570deu
dc.titleAnalysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafisheng
dc.typeJOURNAL_ARTICLEdeu
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@article{Gibert2005Analy-7692,
  year={2005},
  doi={10.1016/j.gene.2005.05.015},
  title={Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish},
  number={2},
  volume={353},
  issn={0378-1119},
  journal={Gene},
  pages={200--206},
  author={Gibert, Yann and McMillan, D. Randy and Kayes-Wandover, Kathleen and Meyer, Axel and Begemann, Gerrit and White, Perrin C.}
}
kops.citation.iso690GIBERT, Yann, D. Randy MCMILLAN, Kathleen KAYES-WANDOVER, Axel MEYER, Gerrit BEGEMANN, Perrin C. WHITE, 2005. Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish. In: Gene. 2005, 353(2), pp. 200-206. ISSN 0378-1119. Available under: doi: 10.1016/j.gene.2005.05.015deu
kops.citation.iso690GIBERT, Yann, D. Randy MCMILLAN, Kathleen KAYES-WANDOVER, Axel MEYER, Gerrit BEGEMANN, Perrin C. WHITE, 2005. Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish. In: Gene. 2005, 353(2), pp. 200-206. ISSN 0378-1119. Available under: doi: 10.1016/j.gene.2005.05.015eng
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