Publikation:

Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish

Vorschaubild

Dateien

analysis_of_the_very_large_g_protein_coupled_receptor_gene_in_zebrafish.pdf
analysis_of_the_very_large_g_protein_coupled_receptor_gene_in_zebrafish.pdfGröße: 292.46 KBDownloads: 669

Datum

2005

Autor:innen

Gibert, Yann
McMillan, D. Randy
Kayes-Wandover, Kathleen
White, Perrin C.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-33862
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.gene.2005.05.015
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Attribution-NonCommercial-NoDerivs 2.0 Generic

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Gene. 2005, 353(2), pp. 200-206. ISSN 0378-1119. Available under: doi: 10.1016/j.gene.2005.05.015

Zusammenfassung

Very Large G-protein coupled Receptor-1 (VLGR1/Mass1/USH2C) is the largest known cell surface protein in vertebrates. Mutations in VLGR1 are associated with audiogenic epilepsy in mice and Usher syndrome (sensorineural deafness and retinitis pigmentosa) in humans. We characterized the zebrafish VLGR1 gene (vlgr1). It is 51% identical to human VLGR1 in amino acid sequence, but is 64% identical in the 7-transmembrane and cytoplasmic domains. It is 6199 amino acids in size and is encoded by a 19.2 kb mRNA. All introns correspond in location and phase to those of the human and mouse genes. In situ hybridization studies of zebrafish embryos demonstrate vlgr1 expression in the developing central nervous system, particularly in the hypothalamus, epiphysis and in the rhombic lips. Expression in the eye is associated with the optic nerve. Further studies using zebrafish may help ascertain the role of Vlgr1 in neural development.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Usher syndrome, In situ hybridization, Diencephalon, Optic nerve, Zebrafish

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690GIBERT, Yann, D. Randy MCMILLAN, Kathleen KAYES-WANDOVER, Axel MEYER, Gerrit BEGEMANN, Perrin C. WHITE, 2005. Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish. In: Gene. 2005, 353(2), pp. 200-206. ISSN 0378-1119. Available under: doi: 10.1016/j.gene.2005.05.015
BibTex
@article{Gibert2005Analy-7692,
  year={2005},
  doi={10.1016/j.gene.2005.05.015},
  title={Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish},
  number={2},
  volume={353},
  issn={0378-1119},
  journal={Gene},
  pages={200--206},
  author={Gibert, Yann and McMillan, D. Randy and Kayes-Wandover, Kathleen and Meyer, Axel and Begemann, Gerrit and White, Perrin C.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7692">
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7692/1/analysis_of_the_very_large_g_protein_coupled_receptor_gene_in_zebrafish.pdf"/>
    <dc:creator>Meyer, Axel</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Gene 353 (2005), pp. 200 206</dcterms:bibliographicCitation>
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7692"/>
    <dc:contributor>McMillan, D. Randy</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>White, Perrin C.</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:26Z</dcterms:available>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Meyer, Axel</dc:contributor>
    <dc:creator>McMillan, D. Randy</dc:creator>
    <dcterms:abstract xml:lang="eng">Very Large G-protein coupled Receptor-1 (VLGR1/Mass1/USH2C) is the largest known cell surface protein in vertebrates. Mutations in VLGR1 are associated with audiogenic epilepsy in mice and Usher syndrome (sensorineural deafness and retinitis pigmentosa) in humans. We characterized the zebrafish VLGR1 gene (vlgr1). It is 51% identical to human VLGR1 in amino acid sequence, but is 64% identical in the 7-transmembrane and cytoplasmic domains. It is 6199 amino acids in size and is encoded by a 19.2 kb mRNA. All introns correspond in location and phase to those of the human and mouse genes. In situ hybridization studies of zebrafish embryos demonstrate vlgr1 expression in the developing central nervous system, particularly in the hypothalamus, epiphysis and in the rhombic lips. Expression in the eye is associated with the optic nerve. Further studies using zebrafish may help ascertain the role of Vlgr1 in neural development.</dcterms:abstract>
    <dc:contributor>Kayes-Wandover, Kathleen</dc:contributor>
    <dc:contributor>White, Perrin C.</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:26Z</dc:date>
    <dc:language>eng</dc:language>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7692/1/analysis_of_the_very_large_g_protein_coupled_receptor_gene_in_zebrafish.pdf"/>
    <dcterms:title>Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish</dcterms:title>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Gibert, Yann</dc:creator>
    <dc:creator>Kayes-Wandover, Kathleen</dc:creator>
    <dcterms:issued>2005</dcterms:issued>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
    <dc:creator>Begemann, Gerrit</dc:creator>
    <dc:contributor>Gibert, Yann</dc:contributor>
    <dc:contributor>Begemann, Gerrit</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:format>application/pdf</dc:format>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen