Cytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates : synthesis, aqueous stability and X-ray structure analysis

Kurzanzeige
dc.contributor.authorSchneider, Fabian
dc.contributor.authorZhao, Tiankun
dc.contributor.authorHuhn, Thomas
dc.date.accessioned2017-02-01T08:28:30Z
dc.date.available2017-02-01T08:28:30Z
dc.date.issued2016eng
dc.description.abstractHerein we report the synthesis and structural characterization of a series of novel Zr(IV)salan complexes. The initial metalation product [(L1)2Zr] is highly water sensitive while ligand exchanged [L1Zr(dipic)] hydrolyses slowly with a bis-hydroxo Zr(IV) species identified by MS as an intermediate. [L1Zr(dipic)] is cytotoxic in the range of cisplatin against two human carcinoma cell lines.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1039/C6CC05359Aeng
dc.identifier.ppn482813555
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/37041
dc.language.isoengeng
dc.rightsAttribution-NonCommercial 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.subject.ddc540eng
dc.titleCytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates : synthesis, aqueous stability and X-ray structure analysiseng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Schneider2016Cytot-37041,
  year={2016},
  doi={10.1039/C6CC05359A},
  title={Cytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates : synthesis, aqueous stability and X-ray structure analysis},
  number={66},
  volume={52},
  issn={1359-7345},
  journal={Chemical Communications : ChemComm},
  pages={10151--10154},
  author={Schneider, Fabian and Zhao, Tiankun and Huhn, Thomas}
}
kops.citation.iso690SCHNEIDER, Fabian, Tiankun ZHAO, Thomas HUHN, 2016. Cytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates : synthesis, aqueous stability and X-ray structure analysis. In: Chemical Communications : ChemComm. 2016, 52(66), pp. 10151-10154. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/C6CC05359Adeu
kops.citation.iso690SCHNEIDER, Fabian, Tiankun ZHAO, Thomas HUHN, 2016. Cytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates : synthesis, aqueous stability and X-ray structure analysis. In: Chemical Communications : ChemComm. 2016, 52(66), pp. 10151-10154. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/C6CC05359Aeng
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