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Cytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates : synthesis, aqueous stability and X-ray structure analysis

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2016

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http://nbn-resolving.de/urn:nbn:de:bsz:352-0-364499
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https://doi.org/10.1039/C6CC05359A
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Attribution-NonCommercial 3.0 Unported

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Chemical Communications : ChemComm. 2016, 52(66), pp. 10151-10154. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/C6CC05359A

Zusammenfassung

Herein we report the synthesis and structural characterization of a series of novel Zr(IV)salan complexes. The initial metalation product [(L1)2Zr] is highly water sensitive while ligand exchanged [L1Zr(dipic)] hydrolyses slowly with a bis-hydroxo Zr(IV) species identified by MS as an intermediate. [L1Zr(dipic)] is cytotoxic in the range of cisplatin against two human carcinoma cell lines.

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540 Chemie

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ISO 690SCHNEIDER, Fabian, Tiankun ZHAO, Thomas HUHN, 2016. Cytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates : synthesis, aqueous stability and X-ray structure analysis. In: Chemical Communications : ChemComm. 2016, 52(66), pp. 10151-10154. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/C6CC05359A
BibTex
@article{Schneider2016Cytot-37041,
  year={2016},
  doi={10.1039/C6CC05359A},
  title={Cytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates : synthesis, aqueous stability and X-ray structure analysis},
  number={66},
  volume={52},
  issn={1359-7345},
  journal={Chemical Communications : ChemComm},
  pages={10151--10154},
  author={Schneider, Fabian and Zhao, Tiankun and Huhn, Thomas}
}
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