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TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging

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2025

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Novazzi, Federica
Spezia, Pietro Giorgio
Ferrante, Francesca Drago
Genoni, Angelo Paolo
Grossi, Paolo Antonio
Mancini, Nicasio
Malavolta, Marco
Ballietti, Marta
Piacenza, Francesco
Marcozzi, Serena
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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1uvjj68tlyzns5
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https://doi.org/10.1002/jmv.70656
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Journal of Medical Virology. Wiley. 2025, 97(11), e70656. ISSN 0146-6615. eISSN 1096-9071. Verfügbar unter: doi: 10.1002/jmv.70656

Zusammenfassung

Torquetenovirus (TTV) is a prevalent virus whose clinical significance remains unclear, potentially linked to immunosenescence. This study examines TTV species in relation to immune impairment, inflammation, and cellular stress response in aging. A subset of recruited age‐stratified individuals (RASIG) from the MARK‐AGE study was divided into three groups: Cohort 1 A (healthy young adults), Cohort 1B (older adults with mild immune decline), and Cohort 1 C (older adults with marked immune impairment). Analyses included TTV load, species diversity, lymphocyte subpopulations, inflammatory markers, Poly‐(ADP‐ribose) polymerase (PARP‐1) expression/activity. Alpha‐ and beta‐diversity analyses showed the highest TTV species diversity in Cohort 1 C, with significant cohort‐dependent differences and partially cohort‐specific clustering patterns. Increased TTV species number correlated with higher TTV load, elevated CMV IgG levels, and greater immune impairment risk. Specific TTV species were associated with CD4/CD8, and reduced T‐cell receptor excision circles, suggesting impaired T‐cell homeostasis. TTV viremia positively correlated with C‐reactive protein (CRP) and α2‐macroglobulin. PARP‐1 expression and activity increased in individuals with higher TTV diversity, particularly in the presence of TTV9 and TTV20. TTV load and species diversity are associated with immunosenescence, inflammation, and PARP‐1 activation suggesting their potential as biomarkers of age‐related immune decline. Longitudinal studies are needed to clarify underlying mechanisms.

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570 Biowissenschaften, Biologie

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ISO 690NOVAZZI, Federica, Pietro Giorgio SPEZIA, Francesca Drago FERRANTE, Angelo Paolo GENONI, Paolo Antonio GROSSI, Nicasio MANCINI, Marco MALAVOLTA, Marta BALLIETTI, Francesco PIACENZA, Serena MARCOZZI, Carlo FORTUNATO, Gretta Veronica BADILLO PAZMAY, Laura CIANFRUGLIA, Alexander BÜRKLE, Maria MORENO-VILLANUEVA, Martijn E. T. DOLLÉ, Eugène JANSEN, Tilman GRUNE, Efstathios S. GONOS, Claudio FRANCESCHI, Miriam CAPRI, Michele ZAMPIERI, Paola CAIAFA, Fabio CICCARONE, Anna REALE, Birgit WEINBERGER, Ewa SIKORA, Florence DEBACQ‐CHAINIAUX, Wolfgang STUETZ, Mikko HURME, P. Eline SLAGBOOM, Jürgen BERNHARDT, Fabiola OLIVIERI, Fabio FILIPPINI, Fabrizio MAGGI, Robertina GIACCONI, 2025. TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging. In: Journal of Medical Virology. Wiley. 2025, 97(11), e70656. ISSN 0146-6615. eISSN 1096-9071. Verfügbar unter: doi: 10.1002/jmv.70656
BibTex
@article{Novazzi2025-11Speci-76184,
  title={TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging},
  year={2025},
  doi={10.1002/jmv.70656},
  number={11},
  volume={97},
  issn={0146-6615},
  journal={Journal of Medical Virology},
  author={Novazzi, Federica and Spezia, Pietro Giorgio and Ferrante, Francesca Drago and Genoni, Angelo Paolo and Grossi, Paolo Antonio and Mancini, Nicasio and Malavolta, Marco and Ballietti, Marta and Piacenza, Francesco and Marcozzi, Serena and Fortunato, Carlo and Badillo Pazmay, Gretta Veronica and Cianfruglia, Laura and Bürkle, Alexander and Moreno-Villanueva, Maria and Dollé, Martijn E. T. and Jansen, Eugène and Grune, Tilman and Gonos, Efstathios S. and Franceschi, Claudio and Capri, Miriam and Zampieri, Michele and Caiafa, Paola and Ciccarone, Fabio and Reale, Anna and Weinberger, Birgit and Sikora, Ewa and Debacq‐Chainiaux, Florence and Stuetz, Wolfgang and Hurme, Mikko and Slagboom, P. Eline and Bernhardt, Jürgen and Olivieri, Fabiola and Filippini, Fabio and Maggi, Fabrizio and Giacconi, Robertina},
  note={Article Number: e70656}
}
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