Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein Alpha-Synuclein as revealed by Ion mobility mass spectrometry

Kurzanzeige
dc.contributor.authorVlad, Camelia
dc.contributor.authorLindner, Kathrin
dc.contributor.authorKarreman, Christiaan
dc.contributor.authorSchildknecht, Stefan
dc.contributor.authorLeist, Marcel
dc.contributor.authorTomczyk, Nickdeu
dc.contributor.authorRontree, Johndeu
dc.contributor.authorLangridge, Jamesdeu
dc.contributor.authorDanzer, Karindeu
dc.contributor.authorCiossek, Thomasdeu
dc.contributor.authorPetre, Alinadeu
dc.contributor.authorGross, Michael L.deu
dc.contributor.authorHengerer, Bastiandeu
dc.contributor.authorPrzybylski, Michael
dc.date.accessioned2012-01-24T09:58:17Zdeu
dc.date.available2012-01-24T09:58:17Zdeu
dc.date.issued2011-12-16
dc.description.abstractGas-phase protein separation by ion mobility: With its ability to separate the Parkinson's disease protein Alpha-synuclein and its autoproteolytic products—despite the small concentrations of the latter—ion-mobility MS has enabled the characterization of intermediate fragments in in vitro oligomerization-aggregation. In particular, a possible key fragment, the highly aggregating C-terminal fragment, AlphaSyn(72–140), has been revealed.eng
dc.description.versionpublished
dc.identifier.citationFirst publ. in: ChemBioChem ; 12 (2011), 18. - pp. 2740–2744deu
dc.identifier.doi10.1002/cbic.201100569deu
dc.identifier.pmid22162214
dc.identifier.ppn357816145deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/17016
dc.language.isoengdeu
dc.legacy.dateIssued2012-01-24deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectAggregationdeu
dc.subjectalpha-synucleindeu
dc.subjectautoproteolytic fragmentationdeu
dc.subjectmass spectrometrydeu
dc.subjectoligomerizationdeu
dc.subject.ddc540deu
dc.titleAutoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein Alpha-Synuclein as revealed by Ion mobility mass spectrometryeng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
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@article{Vlad2011-12-16Autop-17016,
  year={2011},
  doi={10.1002/cbic.201100569},
  title={Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein Alpha-Synuclein as revealed by Ion mobility mass spectrometry},
  number={18},
  volume={12},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={2740--2744},
  author={Vlad, Camelia and Lindner, Kathrin and Karreman, Christiaan and Schildknecht, Stefan and Leist, Marcel and Tomczyk, Nick and Rontree, John and Langridge, James and Danzer, Karin and Ciossek, Thomas and Petre, Alina and Gross, Michael L. and Hengerer, Bastian and Przybylski, Michael}
}
kops.citation.iso690VLAD, Camelia, Kathrin LINDNER, Christiaan KARREMAN, Stefan SCHILDKNECHT, Marcel LEIST, Nick TOMCZYK, John RONTREE, James LANGRIDGE, Karin DANZER, Thomas CIOSSEK, Alina PETRE, Michael L. GROSS, Bastian HENGERER, Michael PRZYBYLSKI, 2011. Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein Alpha-Synuclein as revealed by Ion mobility mass spectrometry. In: ChemBioChem. 2011, 12(18), pp. 2740-2744. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100569deu
kops.citation.iso690VLAD, Camelia, Kathrin LINDNER, Christiaan KARREMAN, Stefan SCHILDKNECHT, Marcel LEIST, Nick TOMCZYK, John RONTREE, James LANGRIDGE, Karin DANZER, Thomas CIOSSEK, Alina PETRE, Michael L. GROSS, Bastian HENGERER, Michael PRZYBYLSKI, 2011. Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein Alpha-Synuclein as revealed by Ion mobility mass spectrometry. In: ChemBioChem. 2011, 12(18), pp. 2740-2744. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100569eng
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kops.sourcefieldChemBioChem. 2011, <b>12</b>(18), pp. 2740-2744. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100569deu
kops.sourcefield.plainChemBioChem. 2011, 12(18), pp. 2740-2744. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100569deu
kops.sourcefield.plainChemBioChem. 2011, 12(18), pp. 2740-2744. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100569eng
kops.submitter.emailoleg.kozlov@uni-konstanz.dedeu
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