Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein Alpha-Synuclein as revealed by Ion mobility mass spectrometry

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2011
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Tomczyk, Nick
Rontree, John
Langridge, James
Danzer, Karin
Ciossek, Thomas
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ChemBioChem. 2011, 12(18), pp. 2740-2744. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100569
Zusammenfassung

Gas-phase protein separation by ion mobility: With its ability to separate the Parkinson's disease protein Alpha-synuclein and its autoproteolytic products—despite the small concentrations of the latter—ion-mobility MS has enabled the characterization of intermediate fragments in in vitro oligomerization-aggregation. In particular, a possible key fragment, the highly aggregating C-terminal fragment, AlphaSyn(72–140), has been revealed.

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540 Chemie
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Aggregation, alpha-synuclein, autoproteolytic fragmentation, mass spectrometry, oligomerization
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ISO 690VLAD, Camelia, Kathrin LINDNER, Christiaan KARREMAN, Stefan SCHILDKNECHT, Marcel LEIST, Nick TOMCZYK, John RONTREE, James LANGRIDGE, Karin DANZER, Thomas CIOSSEK, Alina PETRE, Michael L. GROSS, Bastian HENGERER, Michael PRZYBYLSKI, 2011. Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein Alpha-Synuclein as revealed by Ion mobility mass spectrometry. In: ChemBioChem. 2011, 12(18), pp. 2740-2744. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100569
BibTex
@article{Vlad2011-12-16Autop-17016,
  year={2011},
  doi={10.1002/cbic.201100569},
  title={Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein Alpha-Synuclein as revealed by Ion mobility mass spectrometry},
  number={18},
  volume={12},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={2740--2744},
  author={Vlad, Camelia and Lindner, Kathrin and Karreman, Christiaan and Schildknecht, Stefan and Leist, Marcel and Tomczyk, Nick and Rontree, John and Langridge, James and Danzer, Karin and Ciossek, Thomas and Petre, Alina and Gross, Michael L. and Hengerer, Bastian and Przybylski, Michael}
}
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