lGnRH-III - a Promising Candidate for Anticancer Drug Development

Kurzanzeige
dc.contributor.authorManea, Marilena
dc.contributor.authorMező, Gabordeu
dc.date.accessioned2013-03-13T13:52:23Zdeu
dc.date.available2013-03-13T13:52:23Zdeu
dc.date.issued2013
dc.description.abstractLamprey gonadotropin-releasing hormone-III (lGnRH-III; Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2), a native isoform of human GnRH (GnRH-I), was initially isolated from the brain of the sea lamprey (Petromyzon marinus). It is a weak GnRH agonist, which exerts a direct antiproliferative effect on cancer cells and has an insignificant LH and FSH releasing potency in mammals. These features reveal the advantages of lGnRH-III and its derivatives for use in cancer therapy. Here we give an overview of various strategies to increase the antitumor activity of lGnRH-III, such as amino acid replacement, cyclization, dimerization and conjugation to polymers or to chemotherapeutic agents. In vitro and in vivo antitumor activity of lGnRH-III based compounds was demonstrated both on hormone dependent and independent tumors.eng
dc.description.versionpublished
dc.identifier.citationProtein Peptide Letters ; 20 (2013), 4. - S. 439-449deu
dc.identifier.doi10.2174/092986613805290381deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/20568
dc.language.isoengdeu
dc.legacy.dateIssued2013-03-13deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectLamprey gonadotropin-releasing hormone-III (lGnRH-deu
dc.subjectanticancer activitydeu
dc.subjecttargeted cancer chemotherapydeu
dc.subjectanthracyclinesdeu
dc.subjectpeptide dimersdeu
dc.subjectdrug - peptide conjugatesdeu
dc.subjectantiproliferative effectdeu
dc.subjectchemotherapeutic agentdeu
dc.subjecttumordeu
dc.subjectsteroiddeu
dc.subject.ddc540deu
dc.titlelGnRH-III - a Promising Candidate for Anticancer Drug Developmenteng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Manea2013lGnRH-20568,
  year={2013},
  doi={10.2174/092986613805290381},
  title={lGnRH-III - a Promising Candidate for Anticancer Drug Development},
  number={4},
  volume={20},
  issn={0929-8665},
  journal={Protein & Peptide Letters},
  pages={439--449},
  author={Manea, Marilena and Mező, Gabor}
}
kops.citation.iso690MANEA, Marilena, Gabor MEZŐ, 2013. lGnRH-III - a Promising Candidate for Anticancer Drug Development. In: Protein & Peptide Letters. 2013, 20(4), pp. 439-449. ISSN 0929-8665. eISSN 1875-5305. Available under: doi: 10.2174/092986613805290381deu
kops.citation.iso690MANEA, Marilena, Gabor MEZŐ, 2013. lGnRH-III - a Promising Candidate for Anticancer Drug Development. In: Protein & Peptide Letters. 2013, 20(4), pp. 439-449. ISSN 0929-8665. eISSN 1875-5305. Available under: doi: 10.2174/092986613805290381eng
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kops.sourcefield.plainProtein & Peptide Letters. 2013, 20(4), pp. 439-449. ISSN 0929-8665. eISSN 1875-5305. Available under: doi: 10.2174/092986613805290381deu
kops.sourcefield.plainProtein & Peptide Letters. 2013, 20(4), pp. 439-449. ISSN 0929-8665. eISSN 1875-5305. Available under: doi: 10.2174/092986613805290381eng
kops.submitter.emailmarilena.manea@uni-konstanz.dedeu
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source.periodicalTitleProtein & Peptide Letters

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