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lGnRH-III - a Promising Candidate for Anticancer Drug Development

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2013

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Mező, Gabor

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http://nbn-resolving.de/urn:nbn:de:bsz:352-205681
DOI (zitierfähiger Link)
https://doi.org/10.2174/092986613805290381
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Protein & Peptide Letters. 2013, 20(4), pp. 439-449. ISSN 0929-8665. eISSN 1875-5305. Available under: doi: 10.2174/092986613805290381

Zusammenfassung

Lamprey gonadotropin-releasing hormone-III (lGnRH-III; Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH2), a native isoform of human GnRH (GnRH-I), was initially isolated from the brain of the sea lamprey (Petromyzon marinus). It is a weak GnRH agonist, which exerts a direct antiproliferative effect on cancer cells and has an insignificant LH and FSH releasing potency in mammals. These features reveal the advantages of lGnRH-III and its derivatives for use in cancer therapy. Here we give an overview of various strategies to increase the antitumor activity of lGnRH-III, such as amino acid replacement, cyclization, dimerization and conjugation to polymers or to chemotherapeutic agents. In vitro and in vivo antitumor activity of lGnRH-III based compounds was demonstrated both on hormone dependent and independent tumors.

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Fachgebiet (DDC)
540 Chemie

Schlagwörter

Lamprey gonadotropin-releasing hormone-III (lGnRH-, anticancer activity, targeted cancer chemotherapy, anthracyclines, peptide dimers, drug - peptide conjugates, antiproliferative effect, chemotherapeutic agent, tumor, steroid

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ISO 690MANEA, Marilena, Gabor MEZŐ, 2013. lGnRH-III - a Promising Candidate for Anticancer Drug Development. In: Protein & Peptide Letters. 2013, 20(4), pp. 439-449. ISSN 0929-8665. eISSN 1875-5305. Available under: doi: 10.2174/092986613805290381
BibTex
@article{Manea2013lGnRH-20568,
  year={2013},
  doi={10.2174/092986613805290381},
  title={lGnRH-III - a Promising Candidate for Anticancer Drug Development},
  number={4},
  volume={20},
  issn={0929-8665},
  journal={Protein & Peptide Letters},
  pages={439--449},
  author={Manea, Marilena and Mező, Gabor}
}
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