Publikation: Adverse experiences in childhood influence brain responses to emotional stimuli in adult psychiatric patients
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Previous results suggest that early life stress (ELS) may be related to altered cortical responses to emotional stimuli. In a previous study, we found suppressed cortical responses to emotional pictures in psychiatric patients with high-ELS. The present study explored the stability of this effect across time and stimulation conditions. In addition, the relationship between ELS and current life stress was examined, and we probed whether this current life stress was related to the cortical responses. Fifteen patients with high, 16 patients with low-ELS and 15 psychiatrically healthy subjects with low-ELS participated in two sessions 8 months apart. Subjects monitored a rapid serial presentation of pleasant, neutral and unpleasant pictures during magnetoencephalographic recording. In both sessions, estimated neural activity in occipital parietal temporal regions between 70 and 250 ms after picture onset was smaller in patients, particularly in those with high-ELS, compared to healthy subjects. Modulation of activity by arousing (pleasant and unpleasant) compared to neutral stimuli around 200 ms post-stimulus did not differ between groups, whereas around 300 ms, patients did not show the pronounced cortical response to pleasant stimuli exhibited by healthy subjects. Results suggest that ELS and psychiatric disorder (1) diminish early perceptual processing (b200 ms) of emotional stimuli without substantially affecting activity modulation by stimulus arousal value, (2) diminish later attention allocation processes (N300 ms), and (3) are related to more recent life stress. High intraindividual correlations of activity patterns between sessions suggest lasting effects of ELS on processing modes.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
MATZ, Katharina, Markus JUNGHÖFER, Thomas ELBERT, Katja WEBER, Christian WIENBRUCH, Brigitte ROCKSTROH, 2010. Adverse experiences in childhood influence brain responses to emotional stimuli in adult psychiatric patients. In: International Journal of Psychophysiology. 2010, 75(3), pp. 277-286. ISSN 0167-8760. eISSN 1872-7697. Available under: doi: 10.1016/j.ijpsycho.2009.12.010BibTex
@article{Matz2010Adver-10214, year={2010}, doi={10.1016/j.ijpsycho.2009.12.010}, title={Adverse experiences in childhood influence brain responses to emotional stimuli in adult psychiatric patients}, number={3}, volume={75}, issn={0167-8760}, journal={International Journal of Psychophysiology}, pages={277--286}, author={Matz, Katharina and Junghöfer, Markus and Elbert, Thomas and Weber, Katja and Wienbruch, Christian and Rockstroh, Brigitte} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/10214"> <dc:creator>Weber, Katja</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/10214/1/Matz_Adverse_experiences.pdf"/> <dcterms:abstract xml:lang="eng">Previous results suggest that early life stress (ELS) may be related to altered cortical responses to emotional stimuli. In a previous study, we found suppressed cortical responses to emotional pictures in psychiatric patients with high-ELS. The present study explored the stability of this effect across time and stimulation conditions. In addition, the relationship between ELS and current life stress was examined, and we probed whether this current life stress was related to the cortical responses. Fifteen patients with high, 16 patients with low-ELS and 15 psychiatrically healthy subjects with low-ELS participated in two sessions 8 months apart. Subjects monitored a rapid serial presentation of pleasant, neutral and unpleasant pictures during magnetoencephalographic recording. In both sessions, estimated neural activity in occipital parietal temporal regions between 70 and 250 ms after picture onset was smaller in patients, particularly in those with high-ELS, compared to healthy subjects. Modulation of activity by arousing (pleasant and unpleasant) compared to neutral stimuli around 200 ms post-stimulus did not differ between groups, whereas around 300 ms, patients did not show the pronounced cortical response to pleasant stimuli exhibited by healthy subjects. Results suggest that ELS and psychiatric disorder (1) diminish early perceptual processing (b200 ms) of emotional stimuli without substantially affecting activity modulation by stimulus arousal value, (2) diminish later attention allocation processes (N300 ms), and (3) are related to more recent life stress. High intraindividual correlations of activity patterns between sessions suggest lasting effects of ELS on processing modes.</dcterms:abstract> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/> <dc:contributor>Weber, Katja</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/10214"/> <dc:creator>Junghöfer, Markus</dc:creator> <dc:creator>Matz, Katharina</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-25T09:15:10Z</dcterms:available> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dc:format>application/pdf</dc:format> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/> <dc:contributor>Elbert, Thomas</dc:contributor> <dc:creator>Wienbruch, Christian</dc:creator> <dcterms:title>Adverse experiences in childhood influence brain responses to emotional stimuli in adult psychiatric patients</dcterms:title> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/10214/1/Matz_Adverse_experiences.pdf"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-25T09:15:10Z</dc:date> <dc:contributor>Rockstroh, Brigitte</dc:contributor> <dc:creator>Rockstroh, Brigitte</dc:creator> <dcterms:bibliographicCitation>First publ. in: International Journal of Psychophysiology 75 (2010), 3, pp. 277 286</dcterms:bibliographicCitation> <dc:contributor>Wienbruch, Christian</dc:contributor> <dc:contributor>Matz, Katharina</dc:contributor> <dc:creator>Elbert, Thomas</dc:creator> <dc:contributor>Junghöfer, Markus</dc:contributor> <dcterms:issued>2010</dcterms:issued> <dc:rights>terms-of-use</dc:rights> </rdf:Description> </rdf:RDF>