The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense
| dc.contributor.author | Basler, Michael | |
| dc.contributor.author | Buerger, Stefanie | |
| dc.contributor.author | Groettrup, Marcus | |
| dc.date.accessioned | 2015-12-22T07:57:14Z | |
| dc.date.available | 2015-12-22T07:57:14Z | |
| dc.date.issued | 2015 | eng |
| dc.description.abstract | The ubiquitin-like modifier (ULM) HLA-F adjacent transcript 10 (FAT10) is encoded in the MHC locus, is up-regulated during dendritic cell maturation, is highly expressed in lymphoid tissues, and strongly induced by interferon (IFN)-γ and tumor necrosis factor (TNF)-α. FAT10 is the only ULM known to date which directly targets its hundreds of substrates for degradation by the proteasome. This implies a role for FAT10 in antigen presentation. Indeed, fusion of FAT10 to viral proteins enhanced their presentation along the proteasome dependent MHC class I presentation pathway. In this review we discuss the FAT10 conjugation system as an alternative and distinct pathway for MHC class I and II antigen processing. Furthermore, we review the recent finding that FAT10 plays a role in antimicrobial defense against intracellular pathogens. | eng |
| dc.description.version | published | eng |
| dc.identifier.doi | 10.1016/j.molimm.2015.04.012 | eng |
| dc.identifier.pmid | 25983082 | eng |
| dc.identifier.ppn | 475853873 | |
| dc.identifier.uri | https://kops.uni-konstanz.de/handle/123456789/32499 | |
| dc.language.iso | eng | eng |
| dc.rights | terms-of-use | |
| dc.rights.uri | https://rightsstatements.org/page/InC/1.0/ | |
| dc.subject.ddc | 570 | eng |
| dc.title | The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense | eng |
| dc.type | JOURNAL_ARTICLE | eng |
| dspace.entity.type | Publication | |
| kops.citation.bibtex | @article{Basler2015ubiqu-32499,
year={2015},
doi={10.1016/j.molimm.2015.04.012},
title={The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense},
number={2},
volume={68},
issn={0161-5890},
journal={Molecular Immunology},
pages={129--132},
author={Basler, Michael and Buerger, Stefanie and Gröttrup, Marcus}
} | |
| kops.citation.iso690 | BASLER, Michael, Stefanie BUERGER, Marcus GRÖTTRUP, 2015. The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense. In: Molecular Immunology. 2015, 68(2), pp. 129-132. ISSN 0161-5890. eISSN 1872-9142. Available under: doi: 10.1016/j.molimm.2015.04.012 | deu |
| kops.citation.iso690 | BASLER, Michael, Stefanie BUERGER, Marcus GRÖTTRUP, 2015. The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense. In: Molecular Immunology. 2015, 68(2), pp. 129-132. ISSN 0161-5890. eISSN 1872-9142. Available under: doi: 10.1016/j.molimm.2015.04.012 | eng |
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