Publikation:

The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense

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2015

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http://nbn-resolving.de/urn:nbn:de:bsz:352-0-313521
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https://doi.org/10.1016/j.molimm.2015.04.012
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Molecular Immunology. 2015, 68(2), pp. 129-132. ISSN 0161-5890. eISSN 1872-9142. Available under: doi: 10.1016/j.molimm.2015.04.012

Zusammenfassung

The ubiquitin-like modifier (ULM) HLA-F adjacent transcript 10 (FAT10) is encoded in the MHC locus, is up-regulated during dendritic cell maturation, is highly expressed in lymphoid tissues, and strongly induced by interferon (IFN)-γ and tumor necrosis factor (TNF)-α. FAT10 is the only ULM known to date which directly targets its hundreds of substrates for degradation by the proteasome. This implies a role for FAT10 in antigen presentation. Indeed, fusion of FAT10 to viral proteins enhanced their presentation along the proteasome dependent MHC class I presentation pathway. In this review we discuss the FAT10 conjugation system as an alternative and distinct pathway for MHC class I and II antigen processing. Furthermore, we review the recent finding that FAT10 plays a role in antimicrobial defense against intracellular pathogens.

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570 Biowissenschaften, Biologie

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ISO 690BASLER, Michael, Stefanie BUERGER, Marcus GRÖTTRUP, 2015. The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense. In: Molecular Immunology. 2015, 68(2), pp. 129-132. ISSN 0161-5890. eISSN 1872-9142. Available under: doi: 10.1016/j.molimm.2015.04.012
BibTex
@article{Basler2015ubiqu-32499,
  year={2015},
  doi={10.1016/j.molimm.2015.04.012},
  title={The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense},
  number={2},
  volume={68},
  issn={0161-5890},
  journal={Molecular Immunology},
  pages={129--132},
  author={Basler, Michael and Buerger, Stefanie and Gröttrup, Marcus}
}
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