Understanding the impact of 5-HTTLPR, antidepressants, and acute tryptophan depletion on brain activation during facial emotion processing : A review of the imaging literature

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dc.contributor.authorRaab, Kyeon
dc.contributor.authorKirsch, Peter
dc.contributor.authorMier, Daniela
dc.date.accessioned2019-02-27T10:54:34Z
dc.date.available2019-02-27T10:54:34Z
dc.date.issued2016eng
dc.description.abstractDetecting and evaluating emotional information from facial expressions as a basis for behavioural adaption belong to the core social-cognitive abilities of mankind. Dysfunctions in emotional face processing are observed in several major psychiatric disorders like depression and schizophrenia. In search for psychiatric disease biomarkers using the imaging genetics approach, serotonergic gene polymorphisms have been associated with altered brain circuit activation during emotional face processing. Especially the 5-HTTLPR gene polymorphism has been extensively investigated in association with emotion regulation processes. In this article, imaging genetics literature on emotional face processing, reporting genetic effects of 5-HTTLPR in healthy volunteers is reviewed. Additionally, these results are regarded in relation to pharmacologic challenge (antidepressants, acute tryptophan depletion) imaging studies and discussed in light of recent neurobiological evidence with a focus on serotonin (5-HT1A, 5-HT2C, 5-HT2A) receptor findings.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1016/j.neubiorev.2016.08.031eng
dc.identifier.pmid27593442eng
dc.identifier.ppn168617473X
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/45232
dc.language.isoengeng
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dc.subject5-HTTLPR, Acute tryptophan depletion, Amygdala, Anterior cingulate cortex, Candidate gene, Corticolimbic, Emotion, Emotion recognition, Face processing, Imaging genetics, Medial prefrontal cortex, Orbitofrontal cortex, Serotonin, Serotonin receptor, Serotonin transporter, Social cognition, SSRIeng
dc.subject.ddc150eng
dc.titleUnderstanding the impact of 5-HTTLPR, antidepressants, and acute tryptophan depletion on brain activation during facial emotion processing : A review of the imaging literatureeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
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@article{Raab2016Under-45232,
  year={2016},
  doi={10.1016/j.neubiorev.2016.08.031},
  title={Understanding the impact of 5-HTTLPR, antidepressants, and acute tryptophan depletion on brain activation during facial emotion processing : A review of the imaging literature},
  volume={71},
  issn={0149-7634},
  journal={Neuroscience & Biobehavioral Reviews},
  pages={176--197},
  author={Raab, Kyeon and Kirsch, Peter and Mier, Daniela}
}
kops.citation.iso690RAAB, Kyeon, Peter KIRSCH, Daniela MIER, 2016. Understanding the impact of 5-HTTLPR, antidepressants, and acute tryptophan depletion on brain activation during facial emotion processing : A review of the imaging literature. In: Neuroscience & Biobehavioral Reviews. 2016, 71, pp. 176-197. ISSN 0149-7634. eISSN 1873-7528. Available under: doi: 10.1016/j.neubiorev.2016.08.031deu
kops.citation.iso690RAAB, Kyeon, Peter KIRSCH, Daniela MIER, 2016. Understanding the impact of 5-HTTLPR, antidepressants, and acute tryptophan depletion on brain activation during facial emotion processing : A review of the imaging literature. In: Neuroscience & Biobehavioral Reviews. 2016, 71, pp. 176-197. ISSN 0149-7634. eISSN 1873-7528. Available under: doi: 10.1016/j.neubiorev.2016.08.031eng
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