Publikation:

Understanding the impact of 5-HTTLPR, antidepressants, and acute tryptophan depletion on brain activation during facial emotion processing : A review of the imaging literature

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Datum

2016

Autor:innen

Raab, Kyeon
Kirsch, Peter

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1rkpt1123ru8b4
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.neubiorev.2016.08.031
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Psychologie: Publikationen
Core Facility der Universität Konstanz

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Published

Erschienen in

Neuroscience & Biobehavioral Reviews. 2016, 71, pp. 176-197. ISSN 0149-7634. eISSN 1873-7528. Available under: doi: 10.1016/j.neubiorev.2016.08.031

Zusammenfassung

Detecting and evaluating emotional information from facial expressions as a basis for behavioural adaption belong to the core social-cognitive abilities of mankind. Dysfunctions in emotional face processing are observed in several major psychiatric disorders like depression and schizophrenia. In search for psychiatric disease biomarkers using the imaging genetics approach, serotonergic gene polymorphisms have been associated with altered brain circuit activation during emotional face processing. Especially the 5-HTTLPR gene polymorphism has been extensively investigated in association with emotion regulation processes. In this article, imaging genetics literature on emotional face processing, reporting genetic effects of 5-HTTLPR in healthy volunteers is reviewed. Additionally, these results are regarded in relation to pharmacologic challenge (antidepressants, acute tryptophan depletion) imaging studies and discussed in light of recent neurobiological evidence with a focus on serotonin (5-HT1A, 5-HT2C, 5-HT2A) receptor findings.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

5-HTTLPR, Acute tryptophan depletion, Amygdala, Anterior cingulate cortex, Candidate gene, Corticolimbic, Emotion, Emotion recognition, Face processing, Imaging genetics, Medial prefrontal cortex, Orbitofrontal cortex, Serotonin, Serotonin receptor, Serotonin transporter, Social cognition, SSRI

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ISO 690RAAB, Kyeon, Peter KIRSCH, Daniela MIER, 2016. Understanding the impact of 5-HTTLPR, antidepressants, and acute tryptophan depletion on brain activation during facial emotion processing : A review of the imaging literature. In: Neuroscience & Biobehavioral Reviews. 2016, 71, pp. 176-197. ISSN 0149-7634. eISSN 1873-7528. Available under: doi: 10.1016/j.neubiorev.2016.08.031
BibTex
@article{Raab2016Under-45232,
  year={2016},
  doi={10.1016/j.neubiorev.2016.08.031},
  title={Understanding the impact of 5-HTTLPR, antidepressants, and acute tryptophan depletion on brain activation during facial emotion processing : A review of the imaging literature},
  volume={71},
  issn={0149-7634},
  journal={Neuroscience & Biobehavioral Reviews},
  pages={176--197},
  author={Raab, Kyeon and Kirsch, Peter and Mier, Daniela}
}
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