Intercellular trafficking of the nuclear oncoprotein DEK

Kurzanzeige
dc.contributor.authorSaha, Anjan K.deu
dc.contributor.authorKappes, Ferdinanddeu
dc.contributor.authorMundade, Amrutadeu
dc.contributor.authorDeutzmann, Anja
dc.contributor.authorRosmarin, David M.deu
dc.contributor.authorLegendre, Maureendeu
dc.contributor.authorChatain, Nicolasdeu
dc.contributor.authorAl-Obaidi, Zeinadeu
dc.contributor.authorAdams, Barbara S.deu
dc.contributor.authorPloegh, Hidde L.deu
dc.contributor.authorFerrando-May, Elisa
dc.contributor.authorMor-Vaknin, Niritdeu
dc.contributor.authorMarkovitz, David M.deu
dc.date.accessioned2013-06-24T09:14:54Zdeu
dc.date.available2013-11-30T23:25:04Zdeu
dc.date.issued2013-04-23
dc.description.abstractDEK is a biochemically distinct, conserved nonhistone protein that is vital to global heterochromatin integrity. In addition, DEK can be secreted and function as a chemotactic, proinflammatory factor. Here we show that exogenous DEK can penetrate cells, translocate to the nucleus, and there carry out its endogenous nuclear functions. Strikingly, adjacent cells can take up DEK secreted from synovial macrophages. DEK internalization is a heparan sulfate-dependent process, and cellular uptake of DEK into DEK knockdown cells corrects global heterochromatin depletion and DNA repair deficits, the phenotypic aberrations characteristic of these cells. These findings thus unify the extracellular and intracellular activities of DEK, and suggest that this paracrine loop involving DEK plays a role in chromatin biology.eng
dc.description.versionpublished
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America : PNAS ; 110 (2013), 17. - S. 6847-6852deu
dc.identifier.doi10.1073/pnas.1220751110deu
dc.identifier.pmid23569252
dc.identifier.ppn38388599Xdeu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/23710
dc.language.isoengdeu
dc.legacy.dateIssued2013-06-24deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectcellular biologydeu
dc.subjectcancerdeu
dc.subjectautoimmunitydeu
dc.subjectjuvenile arthritisdeu
dc.subject.ddc570deu
dc.titleIntercellular trafficking of the nuclear oncoprotein DEKeng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Saha2013-04-23Inter-23710,
  year={2013},
  doi={10.1073/pnas.1220751110},
  title={Intercellular trafficking of the nuclear oncoprotein DEK},
  number={17},
  volume={110},
  issn={0027-8424},
  journal={Proceedings of the National Academy of Sciences},
  pages={6847--6852},
  author={Saha, Anjan K. and Kappes, Ferdinand and Mundade, Amruta and Deutzmann, Anja and Rosmarin, David M. and Legendre, Maureen and Chatain, Nicolas and Al-Obaidi, Zeina and Adams, Barbara S. and Ploegh, Hidde L. and Ferrando-May, Elisa and Mor-Vaknin, Nirit and Markovitz, David M.}
}
kops.citation.iso690SAHA, Anjan K., Ferdinand KAPPES, Amruta MUNDADE, Anja DEUTZMANN, David M. ROSMARIN, Maureen LEGENDRE, Nicolas CHATAIN, Zeina AL-OBAIDI, Barbara S. ADAMS, Hidde L. PLOEGH, Elisa FERRANDO-MAY, Nirit MOR-VAKNIN, David M. MARKOVITZ, 2013. Intercellular trafficking of the nuclear oncoprotein DEK. In: Proceedings of the National Academy of Sciences. 2013, 110(17), pp. 6847-6852. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.1220751110deu
kops.citation.iso690SAHA, Anjan K., Ferdinand KAPPES, Amruta MUNDADE, Anja DEUTZMANN, David M. ROSMARIN, Maureen LEGENDRE, Nicolas CHATAIN, Zeina AL-OBAIDI, Barbara S. ADAMS, Hidde L. PLOEGH, Elisa FERRANDO-MAY, Nirit MOR-VAKNIN, David M. MARKOVITZ, 2013. Intercellular trafficking of the nuclear oncoprotein DEK. In: Proceedings of the National Academy of Sciences. 2013, 110(17), pp. 6847-6852. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.1220751110eng
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kops.submitter.emailchristina.hipper-meier@uni-konstanz.dedeu
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