Publikation:

Intercellular trafficking of the nuclear oncoprotein DEK

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Saha_237101.pdf
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2013

Autor:innen

Saha, Anjan K.
Kappes, Ferdinand
Mundade, Amruta
Rosmarin, David M.
Legendre, Maureen
Chatain, Nicolas
Al-Obaidi, Zeina
Adams, Barbara S.
Ploegh, Hidde L.
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http://nbn-resolving.de/urn:nbn:de:bsz:352-237101
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https://doi.org/10.1073/pnas.1220751110
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Biologie: Publikationen
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Published

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Proceedings of the National Academy of Sciences. 2013, 110(17), pp. 6847-6852. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.1220751110

Zusammenfassung

DEK is a biochemically distinct, conserved nonhistone protein that is vital to global heterochromatin integrity. In addition, DEK can be secreted and function as a chemotactic, proinflammatory factor. Here we show that exogenous DEK can penetrate cells, translocate to the nucleus, and there carry out its endogenous nuclear functions. Strikingly, adjacent cells can take up DEK secreted from synovial macrophages. DEK internalization is a heparan sulfate-dependent process, and cellular uptake of DEK into DEK knockdown cells corrects global heterochromatin depletion and DNA repair deficits, the phenotypic aberrations characteristic of these cells. These findings thus unify the extracellular and intracellular activities of DEK, and suggest that this paracrine loop involving DEK plays a role in chromatin biology.

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570 Biowissenschaften, Biologie

Schlagwörter

cellular biology, cancer, autoimmunity, juvenile arthritis

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ISO 690SAHA, Anjan K., Ferdinand KAPPES, Amruta MUNDADE, Anja DEUTZMANN, David M. ROSMARIN, Maureen LEGENDRE, Nicolas CHATAIN, Zeina AL-OBAIDI, Barbara S. ADAMS, Hidde L. PLOEGH, Elisa FERRANDO-MAY, Nirit MOR-VAKNIN, David M. MARKOVITZ, 2013. Intercellular trafficking of the nuclear oncoprotein DEK. In: Proceedings of the National Academy of Sciences. 2013, 110(17), pp. 6847-6852. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.1220751110
BibTex
@article{Saha2013-04-23Inter-23710,
  year={2013},
  doi={10.1073/pnas.1220751110},
  title={Intercellular trafficking of the nuclear oncoprotein DEK},
  number={17},
  volume={110},
  issn={0027-8424},
  journal={Proceedings of the National Academy of Sciences},
  pages={6847--6852},
  author={Saha, Anjan K. and Kappes, Ferdinand and Mundade, Amruta and Deutzmann, Anja and Rosmarin, David M. and Legendre, Maureen and Chatain, Nicolas and Al-Obaidi, Zeina and Adams, Barbara S. and Ploegh, Hidde L. and Ferrando-May, Elisa and Mor-Vaknin, Nirit and Markovitz, David M.}
}
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