A Sensitivity Analysis of the Optimal Drug Dosing Algorithm OptiDose

Kurzanzeige
dc.contributor.authorBachmann, Freya
dc.contributor.authorKoch, Gilbert
dc.contributor.authorPfister, Marc
dc.contributor.authorSzinnai, Gabor
dc.contributor.authorSchropp, Johannes
dc.date.accessioned2023-09-01T12:39:26Z
dc.date.available2023-09-01T12:39:26Z
dc.date.issued2022
dc.description.abstractOptiDose is a drug dosing algorithm that computes the optimal doses for a given patient and dosing schedule based on control theory. Here, a sensitivity analysis for OptiDose using derivative based and regression methods is performed. Two sensitivity measures with respect to the model parameters are presented, the sensitivity of the optimal doses and the sensitivity of the minimized cost functional. Further, the sensitivity analysis is applied to typical pharmacokinetic-pharmacodynamic examples.eng
dc.description.versionpublished
dc.identifier.ppn1756002061
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/53497.2
dc.language.isoengeng
dc.rightsterms-of-use
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/
dc.subjectsensitivity analysis, optimal control, pharmacometricseng
dc.subject.ddc510eng
dc.subject.msc49K15
dc.subject.msc65K10
dc.subject.msc90C31
dc.subject.msc92C50
dc.titleA Sensitivity Analysis of the Optimal Drug Dosing Algorithm OptiDoseeng
dc.typeJOURNAL_ARTICLE
dspace.entity.typePublication
kops.citation.bibtex
@article{Bachmann2022Sensi-53497.2,
  year={2022},
  title={A Sensitivity Analysis of the Optimal Drug Dosing Algorithm OptiDose},
  url={yokohamapublishers.jp/online2/oppafa/vol7/p1127},
  number={4},
  volume={7},
  issn={2189-3756},
  journal={Pure and Applied Functional Analysis},
  pages={1127--1140},
  author={Bachmann, Freya and Koch, Gilbert and Pfister, Marc and Szinnai, Gabor and Schropp, Johannes}
}
kops.citation.iso690BACHMANN, Freya, Gilbert KOCH, Marc PFISTER, Gabor SZINNAI, Johannes SCHROPP, 2022. A Sensitivity Analysis of the Optimal Drug Dosing Algorithm OptiDose. In: Pure and Applied Functional Analysis. Yokohama Publishers. 2022, 7(4), pp. 1127-1140. ISSN 2189-3756. eISSN 2189-3764deu
kops.citation.iso690BACHMANN, Freya, Gilbert KOCH, Marc PFISTER, Gabor SZINNAI, Johannes SCHROPP, 2022. A Sensitivity Analysis of the Optimal Drug Dosing Algorithm OptiDose. In: Pure and Applied Functional Analysis. Yokohama Publishers. 2022, 7(4), pp. 1127-1140. ISSN 2189-3756. eISSN 2189-3764eng
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kops.sourcefieldPure and Applied Functional Analysis. Yokohama Publishers. 2022, <b>7</b>(4), pp. 1127-1140. ISSN 2189-3756. eISSN 2189-3764deu
kops.sourcefield.plainPure and Applied Functional Analysis. Yokohama Publishers. 2022, 7(4), pp. 1127-1140. ISSN 2189-3756. eISSN 2189-3764deu
kops.sourcefield.plainPure and Applied Functional Analysis. Yokohama Publishers. 2022, 7(4), pp. 1127-1140. ISSN 2189-3756. eISSN 2189-3764eng
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source.periodicalTitlePure and Applied Functional Analysis
source.publisherYokohama Publishers

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