Publikation: A Sensitivity Analysis of the Optimal Drug Dosing Algorithm OptiDose
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2022
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Pure and Applied Functional Analysis. Yokohama Publishers. 2022, 7(4), pp. 1127-1140. ISSN 2189-3756. eISSN 2189-3764
Zusammenfassung
OptiDose is a drug dosing algorithm that computes the optimal doses for a given patient and dosing schedule based on control theory. Here, a sensitivity analysis for OptiDose using derivative based and regression methods is performed. Two sensitivity measures with respect to the model parameters are presented, the sensitivity of the optimal doses and the sensitivity of the minimized cost functional. Further, the sensitivity analysis is applied to typical pharmacokinetic-pharmacodynamic examples.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
510 Mathematik
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sensitivity analysis, optimal control, pharmacometrics
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BACHMANN, Freya, Gilbert KOCH, Marc PFISTER, Gabor SZINNAI, Johannes SCHROPP, 2022. A Sensitivity Analysis of the Optimal Drug Dosing Algorithm OptiDose. In: Pure and Applied Functional Analysis. Yokohama Publishers. 2022, 7(4), pp. 1127-1140. ISSN 2189-3756. eISSN 2189-3764BibTex
@article{Bachmann2022Sensi-53497.2,
year={2022},
title={A Sensitivity Analysis of the Optimal Drug Dosing Algorithm OptiDose},
url={yokohamapublishers.jp/online2/oppafa/vol7/p1127},
number={4},
volume={7},
issn={2189-3756},
journal={Pure and Applied Functional Analysis},
pages={1127--1140},
author={Bachmann, Freya and Koch, Gilbert and Pfister, Marc and Szinnai, Gabor and Schropp, Johannes}
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2023-08-30
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