Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury

Kurzanzeige
dc.contributor.authorHärter, Lucdeu
dc.contributor.authorKeel, Mariusdeu
dc.contributor.authorHentze, Hannesdeu
dc.contributor.authorLeist, Marcel
dc.contributor.authorErtel, Wolfgangdeu
dc.date.accessioned2011-03-24T17:38:01Zdeu
dc.date.available2011-03-24T17:38:01Zdeu
dc.date.issued2001deu
dc.description.abstractLoss of neurons after traumatic brain injury (TBI) might involve dysregulated apoptosis. Activation of caspase-3 is one hallmark of apoptosis. Therefore, caspase-3 activity (cleavage of DEVD-afc) was measured in cerebrospinal fluid (CSF) samples (n=113) from 27 patients with TBI at day 1 t0 14 after trauma. Caspase-3 activity was detected in 31 (27.4%) CSF samples with highest values (> 5.5 mM/min) seen at day 2 5 after trauma. No caspase-3 activity was found in serum from patients or CSF from controls. The presence of activated caspase-3 in CSF suggests ongoing apoptotic processes during traumatic brain injury.eng
dc.description.versionpublished
dc.format.mimetypeapplication/pdfdeu
dc.identifier.citationFirst publ. in: Journal of Neuroimmunology 121 (2001), 1/2, pp. 76-78deu
dc.identifier.doi10.1016/S0165-5728(01)00409-X
dc.identifier.ppn308407474deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/7851
dc.language.isoengdeu
dc.legacy.dateIssued2009deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectApoptosisdeu
dc.subjectNeuronsdeu
dc.subjectTraumadeu
dc.subjectBraindeu
dc.subjectDEVD-afcdeu
dc.subjectzVADdeu
dc.subject.ddc570deu
dc.titleCaspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injuryeng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Harter2001Caspa-7851,
  year={2001},
  doi={10.1016/S0165-5728(01)00409-X},
  title={Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury},
  number={1/2},
  volume={121},
  issn={0165-5728},
  journal={Journal of Neuroimmunology},
  pages={76--78},
  author={Härter, Luc and Keel, Marius and Hentze, Hannes and Leist, Marcel and Ertel, Wolfgang}
}
kops.citation.iso690HÄRTER, Luc, Marius KEEL, Hannes HENTZE, Marcel LEIST, Wolfgang ERTEL, 2001. Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury. In: Journal of Neuroimmunology. 2001, 121(1/2), pp. 76-78. ISSN 0165-5728. Available under: doi: 10.1016/S0165-5728(01)00409-Xdeu
kops.citation.iso690HÄRTER, Luc, Marius KEEL, Hannes HENTZE, Marcel LEIST, Wolfgang ERTEL, 2001. Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury. In: Journal of Neuroimmunology. 2001, 121(1/2), pp. 76-78. ISSN 0165-5728. Available under: doi: 10.1016/S0165-5728(01)00409-Xeng
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