Publikation:

Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury

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JNeuroimm01.pdf
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Datum

2001

Autor:innen

Härter, Luc
Keel, Marius
Hentze, Hannes
Ertel, Wolfgang

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-82304
DOI (zitierfähiger Link)
https://doi.org/10.1016/S0165-5728(01)00409-X
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Open Access-Veröffentlichung
Open Access Green

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Biologie: Publikationen
Core Facility der Universität Konstanz

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Published

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Journal of Neuroimmunology. 2001, 121(1/2), pp. 76-78. ISSN 0165-5728. Available under: doi: 10.1016/S0165-5728(01)00409-X

Zusammenfassung

Loss of neurons after traumatic brain injury (TBI) might involve dysregulated apoptosis. Activation of caspase-3 is one hallmark of apoptosis. Therefore, caspase-3 activity (cleavage of DEVD-afc) was measured in cerebrospinal fluid (CSF) samples (n=113) from 27 patients with TBI at day 1 t0 14 after trauma. Caspase-3 activity was detected in 31 (27.4%) CSF samples with highest values (> 5.5 mM/min) seen at day 2 5 after trauma. No caspase-3 activity was found in serum from patients or CSF from controls. The presence of activated caspase-3 in CSF suggests ongoing apoptotic processes during traumatic brain injury.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Apoptosis, Neurons, Trauma, Brain, DEVD-afc, zVAD

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ISO 690HÄRTER, Luc, Marius KEEL, Hannes HENTZE, Marcel LEIST, Wolfgang ERTEL, 2001. Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury. In: Journal of Neuroimmunology. 2001, 121(1/2), pp. 76-78. ISSN 0165-5728. Available under: doi: 10.1016/S0165-5728(01)00409-X
BibTex
@article{Harter2001Caspa-7851,
  year={2001},
  doi={10.1016/S0165-5728(01)00409-X},
  title={Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury},
  number={1/2},
  volume={121},
  issn={0165-5728},
  journal={Journal of Neuroimmunology},
  pages={76--78},
  author={Härter, Luc and Keel, Marius and Hentze, Hannes and Leist, Marcel and Ertel, Wolfgang}
}
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