Publikation: Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury
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2001
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Journal of Neuroimmunology. 2001, 121(1/2), pp. 76-78. ISSN 0165-5728. Available under: doi: 10.1016/S0165-5728(01)00409-X
Zusammenfassung
Loss of neurons after traumatic brain injury (TBI) might involve dysregulated apoptosis. Activation of caspase-3 is one hallmark of apoptosis. Therefore, caspase-3 activity (cleavage of DEVD-afc) was measured in cerebrospinal fluid (CSF) samples (n=113) from 27 patients with TBI at day 1 t0 14 after trauma. Caspase-3 activity was detected in 31 (27.4%) CSF samples with highest values (> 5.5 mM/min) seen at day 2 5 after trauma. No caspase-3 activity was found in serum from patients or CSF from controls. The presence of activated caspase-3 in CSF suggests ongoing apoptotic processes during traumatic brain injury.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Apoptosis, Neurons, Trauma, Brain, DEVD-afc, zVAD
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HÄRTER, Luc, Marius KEEL, Hannes HENTZE, Marcel LEIST, Wolfgang ERTEL, 2001. Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury. In: Journal of Neuroimmunology. 2001, 121(1/2), pp. 76-78. ISSN 0165-5728. Available under: doi: 10.1016/S0165-5728(01)00409-XBibTex
@article{Harter2001Caspa-7851, year={2001}, doi={10.1016/S0165-5728(01)00409-X}, title={Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury}, number={1/2}, volume={121}, issn={0165-5728}, journal={Journal of Neuroimmunology}, pages={76--78}, author={Härter, Luc and Keel, Marius and Hentze, Hannes and Leist, Marcel and Ertel, Wolfgang} }
RDF
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