Poly(ADP-ribosyl)ation in mammalian ageing

Kurzanzeige
dc.contributor.authorBeneke, Sascha
dc.contributor.authorBürkle, Alexander
dc.date.accessioned2011-03-24T17:27:48Zdeu
dc.date.available2011-03-24T17:27:48Zdeu
dc.date.issued2007deu
dc.description.abstractPoly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA baseexcision repair and other repair pathways. A body of correlative data suggests a link between damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl)ation might act as a factor that limits the rate of ageing.eng
dc.description.versionpublished
dc.format.mimetypeapplication/pdfdeu
dc.identifier.citationFirst publ. in: Nucleic Acids Research 35 (2007), 22, pp. 7456-7465deu
dc.identifier.doi10.1126/sageke.2004.49.re9
dc.identifier.pmid15590998
dc.identifier.ppn304894508deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/6615
dc.language.isoengdeu
dc.legacy.dateIssued2009deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subject.ddc570deu
dc.titlePoly(ADP-ribosyl)ation in mammalian ageingeng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Beneke2007PolyA-6615,
  year={2007},
  doi={10.1126/sageke.2004.49.re9},
  title={Poly(ADP-ribosyl)ation in mammalian ageing},
  number={22},
  volume={35},
  journal={Nucleic Acids Research},
  pages={7456--7465},
  author={Beneke, Sascha and Bürkle, Alexander}
}
kops.citation.iso690BENEKE, Sascha, Alexander BÜRKLE, 2007. Poly(ADP-ribosyl)ation in mammalian ageing. In: Nucleic Acids Research. 2007, 35(22), pp. 7456-7465. eISSN 1539-6150. Available under: doi: 10.1126/sageke.2004.49.re9deu
kops.citation.iso690BENEKE, Sascha, Alexander BÜRKLE, 2007. Poly(ADP-ribosyl)ation in mammalian ageing. In: Nucleic Acids Research. 2007, 35(22), pp. 7456-7465. eISSN 1539-6150. Available under: doi: 10.1126/sageke.2004.49.re9eng
kops.citation.rdf
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/6615">
    <dcterms:abstract xml:lang="eng">Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA baseexcision repair and other repair pathways. A body of correlative data suggests a link between damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl)ation might act as a factor that limits the rate of ageing.</dcterms:abstract>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:27:48Z</dcterms:available>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/6615/1/2007_NucleicAcidsRes_Beneke.pdf"/>
    <dc:format>application/pdf</dc:format>
    <dc:creator>Bürkle, Alexander</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/6615"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:27:48Z</dc:date>
    <dcterms:bibliographicCitation>First publ. in: Nucleic Acids Research 35 (2007), 22, pp. 7456-7465</dcterms:bibliographicCitation>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:title>Poly(ADP-ribosyl)ation in mammalian ageing</dcterms:title>
    <dcterms:issued>2007</dcterms:issued>
    <dc:language>eng</dc:language>
    <dc:contributor>Bürkle, Alexander</dc:contributor>
    <dc:contributor>Beneke, Sascha</dc:contributor>
    <dc:creator>Beneke, Sascha</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/6615/1/2007_NucleicAcidsRes_Beneke.pdf"/>
  </rdf:Description>
</rdf:RDF>
kops.description.openAccessopenaccessgreen
kops.flag.knbibliographytrue
kops.identifier.nbnurn:nbn:de:bsz:352-opus-76253deu
kops.opus.id7625deu
kops.sourcefieldNucleic Acids Research. 2007, <b>35</b>(22), pp. 7456-7465. eISSN 1539-6150. Available under: doi: 10.1126/sageke.2004.49.re9deu
kops.sourcefield.plainNucleic Acids Research. 2007, 35(22), pp. 7456-7465. eISSN 1539-6150. Available under: doi: 10.1126/sageke.2004.49.re9deu
kops.sourcefield.plainNucleic Acids Research. 2007, 35(22), pp. 7456-7465. eISSN 1539-6150. Available under: doi: 10.1126/sageke.2004.49.re9eng
relation.isAuthorOfPublicationb1afc9e3-ff8f-4e83-86b0-400310a75628
relation.isAuthorOfPublication99f10fd7-72b9-483a-9c91-e43d378c52d0
relation.isAuthorOfPublication.latestForDiscoveryb1afc9e3-ff8f-4e83-86b0-400310a75628
source.bibliographicInfo.fromPage7456
source.bibliographicInfo.issue22
source.bibliographicInfo.toPage7465
source.bibliographicInfo.volume35
source.identifier.eissn1539-6150
source.periodicalTitleNucleic Acids Research

Dateien

Originalbündel

Gerade angezeigt 1 - 1 von 1
Vorschaubild nicht verfügbar
Name:
2007_NucleicAcidsRes_Beneke.pdf
Größe:
212.2 KB
Format:
Adobe Portable Document Format
2007_NucleicAcidsRes_Beneke.pdf
2007_NucleicAcidsRes_Beneke.pdfGröße: 212.2 KBDownloads: 544

Sammlungen

Biologie: Publikationen