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Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion

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Structure_and_interactions_of_NCAM.pdf
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2003

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Soroka, Vladislav
Kolkova, Kateryna
Kastrup, Jette S.
Breed, Jason
Kiselyov, Vladislav V.
Poulsen, Flemming M.
Larsen, Ingrid K.
Berezin, Vladimir

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Structure. 2003, 10(10), pp. 1291-1301. ISSN 0969-2126. Available under: doi: 10.1016/j.str.2003.09.006

Zusammenfassung

The neural cell adhesion molecule, NCAM, mediates Ca(2+)-independent cell-cell and cell-substratum adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-non-NCAM molecules) binding. NCAM plays a key role in neural development, regeneration, and synaptic plasticity, including learning and memory consolidation. The crystal structure of a fragment comprising the three N-terminal Ig modules of rat NCAM has been determined to 2.0 A resolution. Based on crystallographic data and biological experiments we present a novel model for NCAM homophilic binding. The Ig1 and Ig2 modules mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), whereas the Ig3 module mediates interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through simultaneous binding to the Ig1 and Ig2 modules. This arrangement results in two perpendicular zippers forming a double zipper-like NCAM adhesion complex.

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570 Biowissenschaften, Biologie

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ISO 690SOROKA, Vladislav, Kateryna KOLKOVA, Jette S. KASTRUP, Kay DIEDERICHS, Jason BREED, Vladislav V. KISELYOV, Flemming M. POULSEN, Ingrid K. LARSEN, Wolfram WELTE, Vladimir BEREZIN, Elisabeth BOCK, Christina KASPER, 2003. Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion. In: Structure. 2003, 10(10), pp. 1291-1301. ISSN 0969-2126. Available under: doi: 10.1016/j.str.2003.09.006
BibTex
@article{Soroka2003Struc-6971,
  year={2003},
  doi={10.1016/j.str.2003.09.006},
  title={Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion},
  number={10},
  volume={10},
  issn={0969-2126},
  journal={Structure},
  pages={1291--1301},
  author={Soroka, Vladislav and Kolkova, Kateryna and Kastrup, Jette S. and Diederichs, Kay and Breed, Jason and Kiselyov, Vladislav V. and Poulsen, Flemming M. and Larsen, Ingrid K. and Welte, Wolfram and Berezin, Vladimir and Bock, Elisabeth and Kasper, Christina}
}
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