Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding

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dc.contributor.authorRobotta, Marta
dc.contributor.authorCattani, Julia
dc.contributor.authorMartins, Juliana Cristina
dc.contributor.authorSubramaniam, Vinod
dc.contributor.authorDrescher, Malte
dc.date.accessioned2017-05-23T08:46:11Z
dc.date.available2017-05-23T08:46:11Z
dc.date.issued2017-03-29eng
dc.description.abstractThe intrinsically disordered human protein alpha-Synuclein (αS) has a prominent role in Parkinson's disease (PD) pathology. Several familial variants of αS are correlated with inherited PD. Disease mutations have been shown to have an impact on lipid membrane binding. Here, using electron paramagnetic resonance spectroscopy in combination with site-directed spin labeling, we show that familial PD-associated variants are structurally defective in membrane binding and alter the local binding properties of the protein.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1021/jacs.6b05335eng
dc.identifier.pmid28298083eng
dc.identifier.ppn1841631868
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/39012
dc.language.isoengeng
dc.subject.ddc540eng
dc.titleAlpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Bindingeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Robotta2017-03-29Alpha-39012,
  year={2017},
  doi={10.1021/jacs.6b05335},
  title={Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding},
  number={12},
  volume={139},
  issn={0002-7863},
  journal={Journal of the American Chemical Society : JACS},
  pages={4254--4257},
  author={Robotta, Marta and Cattani, Julia and Martins, Juliana Cristina and Subramaniam, Vinod and Drescher, Malte}
}
kops.citation.iso690ROBOTTA, Marta, Julia CATTANI, Juliana Cristina MARTINS, Vinod SUBRAMANIAM, Malte DRESCHER, 2017. Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding. In: Journal of the American Chemical Society : JACS. 2017, 139(12), pp. 4254-4257. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/jacs.6b05335deu
kops.citation.iso690ROBOTTA, Marta, Julia CATTANI, Juliana Cristina MARTINS, Vinod SUBRAMANIAM, Malte DRESCHER, 2017. Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding. In: Journal of the American Chemical Society : JACS. 2017, 139(12), pp. 4254-4257. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/jacs.6b05335eng
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