Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding

Lade...
Vorschaubild
Dateien
Robotta_2-107onzb7rsmoq4.pdf
Robotta_2-107onzb7rsmoq4.pdfGröße: 200.83 KBDownloads: 9
Datum
2017
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Link zur Lizenz
oops
EU-Projektnummer
DFG-Projektnummer
Projekt
Open Access-Veröffentlichung
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Journal of the American Chemical Society : JACS. 2017, 139(12), pp. 4254-4257. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/jacs.6b05335
Zusammenfassung

The intrinsically disordered human protein alpha-Synuclein (αS) has a prominent role in Parkinson's disease (PD) pathology. Several familial variants of αS are correlated with inherited PD. Disease mutations have been shown to have an impact on lipid membrane binding. Here, using electron paramagnetic resonance spectroscopy in combination with site-directed spin labeling, we show that familial PD-associated variants are structurally defective in membrane binding and alter the local binding properties of the protein.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690ROBOTTA, Marta, Julia CATTANI, Juliana Cristina MARTINS, Vinod SUBRAMANIAM, Malte DRESCHER, 2017. Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding. In: Journal of the American Chemical Society : JACS. 2017, 139(12), pp. 4254-4257. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/jacs.6b05335
BibTex
@article{Robotta2017-03-29Alpha-39012,
  year={2017},
  doi={10.1021/jacs.6b05335},
  title={Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding},
  number={12},
  volume={139},
  issn={0002-7863},
  journal={Journal of the American Chemical Society : JACS},
  pages={4254--4257},
  author={Robotta, Marta and Cattani, Julia and Martins, Juliana Cristina and Subramaniam, Vinod and Drescher, Malte}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/39012">
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/39012/1/Robotta_2-107onzb7rsmoq4.pdf"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:creator>Martins, Juliana Cristina</dc:creator>
    <dc:language>eng</dc:language>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/39012"/>
    <dc:creator>Subramaniam, Vinod</dc:creator>
    <dc:contributor>Martins, Juliana Cristina</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-23T08:46:11Z</dcterms:available>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:creator>Cattani, Julia</dc:creator>
    <dc:contributor>Subramaniam, Vinod</dc:contributor>
    <dcterms:title>Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding</dcterms:title>
    <dcterms:issued>2017-03-29</dcterms:issued>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-23T08:46:11Z</dc:date>
    <dc:contributor>Drescher, Malte</dc:contributor>
    <dcterms:abstract xml:lang="eng">The intrinsically disordered human protein alpha-Synuclein (αS) has a prominent role in Parkinson's disease (PD) pathology. Several familial variants of αS are correlated with inherited PD. Disease mutations have been shown to have an impact on lipid membrane binding. Here, using electron paramagnetic resonance spectroscopy in combination with site-directed spin labeling, we show that familial PD-associated variants are structurally defective in membrane binding and alter the local binding properties of the protein.</dcterms:abstract>
    <dc:contributor>Robotta, Marta</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/39012/1/Robotta_2-107onzb7rsmoq4.pdf"/>
    <dc:creator>Robotta, Marta</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dc:contributor>Cattani, Julia</dc:contributor>
    <dc:creator>Drescher, Malte</dc:creator>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet