Do Mutations Turn p53 into an Oncogene?

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dc.contributor.authorPitolli, Consuelo
dc.contributor.authorWang, Ying
dc.contributor.authorMancini, Mara
dc.contributor.authorShi, Yufang
dc.contributor.authorMelino, Gerry
dc.contributor.authorAmelio, Ivano
dc.date.accessioned2022-02-21T12:37:31Z
dc.date.available2022-02-21T12:37:31Z
dc.date.issued2019-12-11eng
dc.description.abstractThe key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.eng
dc.description.versionpublishedeng
dc.identifier.doi10.3390/ijms20246241eng
dc.identifier.pmid31835684eng
dc.identifier.ppn179341209X
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/56607
dc.language.isoengeng
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTP53; mutant TP53; gain of function; oncogeniceng
dc.subject.ddc570eng
dc.titleDo Mutations Turn p53 into an Oncogene?eng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Pitolli2019-12-11Mutat-56607,
  year={2019},
  doi={10.3390/ijms20246241},
  title={Do Mutations Turn p53 into an Oncogene?},
  number={24},
  volume={20},
  issn={1661-6596},
  journal={International Journal of Molecular Sciences},
  author={Pitolli, Consuelo and Wang, Ying and Mancini, Mara and Shi, Yufang and Melino, Gerry and Amelio, Ivano},
  note={Article Number: 6241}
}
kops.citation.iso690PITOLLI, Consuelo, Ying WANG, Mara MANCINI, Yufang SHI, Gerry MELINO, Ivano AMELIO, 2019. Do Mutations Turn p53 into an Oncogene?. In: International Journal of Molecular Sciences. MDPI. 2019, 20(24), 6241. ISSN 1661-6596. eISSN 1422-0067. Available under: doi: 10.3390/ijms20246241deu
kops.citation.iso690PITOLLI, Consuelo, Ying WANG, Mara MANCINI, Yufang SHI, Gerry MELINO, Ivano AMELIO, 2019. Do Mutations Turn p53 into an Oncogene?. In: International Journal of Molecular Sciences. MDPI. 2019, 20(24), 6241. ISSN 1661-6596. eISSN 1422-0067. Available under: doi: 10.3390/ijms20246241eng
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