Publikation: Do Mutations Turn p53 into an Oncogene?
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2019
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International Journal of Molecular Sciences. MDPI. 2019, 20(24), 6241. ISSN 1661-6596. eISSN 1422-0067. Available under: doi: 10.3390/ijms20246241
Zusammenfassung
The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
TP53; mutant TP53; gain of function; oncogenic
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PITOLLI, Consuelo, Ying WANG, Mara MANCINI, Yufang SHI, Gerry MELINO, Ivano AMELIO, 2019. Do Mutations Turn p53 into an Oncogene?. In: International Journal of Molecular Sciences. MDPI. 2019, 20(24), 6241. ISSN 1661-6596. eISSN 1422-0067. Available under: doi: 10.3390/ijms20246241BibTex
@article{Pitolli2019-12-11Mutat-56607,
year={2019},
doi={10.3390/ijms20246241},
title={Do Mutations Turn p53 into an Oncogene?},
number={24},
volume={20},
issn={1661-6596},
journal={International Journal of Molecular Sciences},
author={Pitolli, Consuelo and Wang, Ying and Mancini, Mara and Shi, Yufang and Melino, Gerry and Amelio, Ivano},
note={Article Number: 6241}
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<dcterms:abstract xml:lang="eng">The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.</dcterms:abstract>
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