RNA unwinding activity of SV40 large T antigen
| dc.contributor.author | Scheffner, Martin | |
| dc.contributor.author | Knippers, Rolf | |
| dc.contributor.author | Stahl, Hans | |
| dc.date.accessioned | 2018-06-29T09:33:45Z | |
| dc.date.available | 2018-06-29T09:33:45Z | |
| dc.date.issued | 1989-06 | eng |
| dc.description.abstract | Large T antigen, the regulatory protein encoded by simian virus 40, has DNA helicase activity and unwinds double-stranded DNA at the expense of ATP. T antigen also functions as an RNA helicase separating duplex regions in partially double-stranded RNA substrates. Surprisingly, T antigen RNA helicase activity requires UTP, CTP, or GTP as a cofactor, whereas ATP is an inefficient energy source for the RNA unwinding reaction. Accordingly, T antigen has both an intrinsic non-ATP NTPase activity that is stimulated by single-stranded RNA and an ATPase activity stimulated by single-stranded DNA. Thus, it appears that the bound nucleotide determines whether T antigen acts as an RNA helicase or as a DNA helicase. | eng |
| dc.description.version | published | eng |
| dc.identifier.doi | 10.1016/0092-8674(89)90334-6 | eng |
| dc.identifier.uri | https://kops.uni-konstanz.de/handle/123456789/42736 | |
| dc.language.iso | eng | eng |
| dc.subject.ddc | 570 | eng |
| dc.title | RNA unwinding activity of SV40 large T antigen | eng |
| dc.type | JOURNAL_ARTICLE | eng |
| dspace.entity.type | Publication | |
| kops.citation.bibtex | @article{Scheffner1989-06unwin-42736,
year={1989},
doi={10.1016/0092-8674(89)90334-6},
title={RNA unwinding activity of SV40 large T antigen},
number={6},
volume={57},
issn={0092-8674},
journal={Cell},
pages={955--963},
author={Scheffner, Martin and Knippers, Rolf and Stahl, Hans}
} | |
| kops.citation.iso690 | SCHEFFNER, Martin, Rolf KNIPPERS, Hans STAHL, 1989. RNA unwinding activity of SV40 large T antigen. In: Cell. 1989, 57(6), pp. 955-963. ISSN 0092-8674. eISSN 1097-4172. Available under: doi: 10.1016/0092-8674(89)90334-6 | deu |
| kops.citation.iso690 | SCHEFFNER, Martin, Rolf KNIPPERS, Hans STAHL, 1989. RNA unwinding activity of SV40 large T antigen. In: Cell. 1989, 57(6), pp. 955-963. ISSN 0092-8674. eISSN 1097-4172. Available under: doi: 10.1016/0092-8674(89)90334-6 | eng |
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| kops.sourcefield | Cell. 1989, <b>57</b>(6), pp. 955-963. ISSN 0092-8674. eISSN 1097-4172. Available under: doi: 10.1016/0092-8674(89)90334-6 | deu |
| kops.sourcefield.plain | Cell. 1989, 57(6), pp. 955-963. ISSN 0092-8674. eISSN 1097-4172. Available under: doi: 10.1016/0092-8674(89)90334-6 | deu |
| kops.sourcefield.plain | Cell. 1989, 57(6), pp. 955-963. ISSN 0092-8674. eISSN 1097-4172. Available under: doi: 10.1016/0092-8674(89)90334-6 | eng |
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