Synthesis and biological evaluation of novel EG5 inhibitors

Kurzanzeige
dc.contributor.authorSarli, Vasilikideu
dc.contributor.authorHuemmer, Stefandeu
dc.contributor.authorSunder-Plassmann, Nilsdeu
dc.contributor.authorMayer, Thomas U.
dc.contributor.authorGiannis, Athanassiosdeu
dc.date.accessioned2012-01-11T09:20:26Zdeu
dc.date.available2012-01-11T09:20:26Zdeu
dc.date.issued2005-11
dc.description.abstractHuman Eg5 is a mitotic kinesin that is essential for bipolar spindle formation and maintenance during mitosis. Recently, the discovery of compounds that inhibit Eg5 and cause mitotic arrest has attracted great interest, due to their potential use as the next generation of antimitotics. Here, we present the synthesis and biological investigation of 3,4-dihydrophenylquinazoline-2(1H)-thiones as selective and potent Eg5 inhibitors.eng
dc.description.versionpublished
dc.identifier.citationPubl. in: Chembiochem ; 6 (2005), 11. - S. 2005-2013deu
dc.identifier.doi10.1002/cbic.200500168deu
dc.identifier.pmid16216042
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/14044
dc.language.isoengdeu
dc.legacy.dateIssued2012-01-11deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectab initio calculationsdeu
dc.subjectinhibitorsdeu
dc.subjectkinesindeu
dc.subjectmitosisdeu
dc.subjectspindledeu
dc.subjectsmall moleculedeu
dc.subjectEg5deu
dc.subjectMitosedeu
dc.subjectChromosomenbandedeu
dc.subjectZellteilungdeu
dc.subject.ddc570deu
dc.titleSynthesis and biological evaluation of novel EG5 inhibitorseng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Sarli2005-11Synth-14044,
  year={2005},
  doi={10.1002/cbic.200500168},
  title={Synthesis and biological evaluation of novel EG5 inhibitors},
  number={11},
  volume={6},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={2005--2013},
  author={Sarli, Vasiliki and Huemmer, Stefan and Sunder-Plassmann, Nils and Mayer, Thomas U. and Giannis, Athanassios}
}
kops.citation.iso690SARLI, Vasiliki, Stefan HUEMMER, Nils SUNDER-PLASSMANN, Thomas U. MAYER, Athanassios GIANNIS, 2005. Synthesis and biological evaluation of novel EG5 inhibitors. In: ChemBioChem. 2005, 6(11), pp. 2005-2013. ISSN 1439-4227. Available under: doi: 10.1002/cbic.200500168deu
kops.citation.iso690SARLI, Vasiliki, Stefan HUEMMER, Nils SUNDER-PLASSMANN, Thomas U. MAYER, Athanassios GIANNIS, 2005. Synthesis and biological evaluation of novel EG5 inhibitors. In: ChemBioChem. 2005, 6(11), pp. 2005-2013. ISSN 1439-4227. Available under: doi: 10.1002/cbic.200500168eng
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kops.sourcefieldChemBioChem. 2005, <b>6</b>(11), pp. 2005-2013. ISSN 1439-4227. Available under: doi: 10.1002/cbic.200500168deu
kops.sourcefield.plainChemBioChem. 2005, 6(11), pp. 2005-2013. ISSN 1439-4227. Available under: doi: 10.1002/cbic.200500168deu
kops.sourcefield.plainChemBioChem. 2005, 6(11), pp. 2005-2013. ISSN 1439-4227. Available under: doi: 10.1002/cbic.200500168eng
kops.submitter.emailmarcus.beck@uni-konstanz.dedeu
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