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Synthesis and biological evaluation of novel EG5 inhibitors

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Datum

2005

Autor:innen

Sarli, Vasiliki
Huemmer, Stefan
Sunder-Plassmann, Nils
Giannis, Athanassios

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-140442
DOI (zitierfähiger Link)
https://doi.org/10.1002/cbic.200500168
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Biologie: Publikationen
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Published

Erschienen in

ChemBioChem. 2005, 6(11), pp. 2005-2013. ISSN 1439-4227. Available under: doi: 10.1002/cbic.200500168

Zusammenfassung

Human Eg5 is a mitotic kinesin that is essential for bipolar spindle formation and maintenance during mitosis. Recently, the discovery of compounds that inhibit Eg5 and cause mitotic arrest has attracted great interest, due to their potential use as the next generation of antimitotics. Here, we present the synthesis and biological investigation of 3,4-dihydrophenylquinazoline-2(1H)-thiones as selective and potent Eg5 inhibitors.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

ab initio calculations, inhibitors, kinesin, mitosis, spindle, small molecule, Eg5, Mitose, Chromosomenbande, Zellteilung

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ISO 690SARLI, Vasiliki, Stefan HUEMMER, Nils SUNDER-PLASSMANN, Thomas U. MAYER, Athanassios GIANNIS, 2005. Synthesis and biological evaluation of novel EG5 inhibitors. In: ChemBioChem. 2005, 6(11), pp. 2005-2013. ISSN 1439-4227. Available under: doi: 10.1002/cbic.200500168
BibTex
@article{Sarli2005-11Synth-14044,
  year={2005},
  doi={10.1002/cbic.200500168},
  title={Synthesis and biological evaluation of novel EG5 inhibitors},
  number={11},
  volume={6},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={2005--2013},
  author={Sarli, Vasiliki and Huemmer, Stefan and Sunder-Plassmann, Nils and Mayer, Thomas U. and Giannis, Athanassios}
}
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